NDLI: Reduction of connexin43 in human endothelial progenitor cells impairs the angiogenic potential

Content Provider	Springer Nature Link
Author	Wang, Hsueh Hsiao Su, Cheng Huang Wu, Yih Jer Li, Jiun Yi Tseng, Ya Ming Lin, Yi Chun Hsieh, Chin Ling Tsai, Cheng Ho Yeh, Hung I
Copyright Year	2013
Abstract	Our previous work showed that arsenic trioxide down-regulated Cx43 and attenuated the angiogenic potential of human late endothelial progenitor cells (EPC). However, the relation between Cx43 and angiogenic activity of the EPC remained unclear. In the study, human late EPC were treated with siRNA specific to Cx43 (Cx43siRNA). The expression profiles as well as activity of the treated cells were examined. In parallel, the angiogenic potential of human EPC treated with Cx43siRNA was evaluated using murine hind limb ischemic model. The results showed that, in the EPC treated with Cx43siRNA, the activity of migration, proliferation, and angiogenic potential were attenuated, accompanied by reduction in vascular endothelial growth factor (VEGF) expression. In hind limb ischemia mice, EPC treated with Cx43siRNA lost the therapeutic angiogenic potential. VEGF supplementation partially recovered the activity impaired by Cx43 down-regulation. In conclusion, reduced Cx43 expression per se in the EPC causes decreased expression of VEGF and impaired angiogenic potential of the cells. Prevention of Cx43 reduction is a potential target to maintain the angiogenic potential of the EPC.
Starting Page	553
Ending Page	560
Page Count	8
File Format	PDF
ISSN	09696970
Journal	Angiogenesis
Volume Number	16
Issue Number	3
e-ISSN	15737209
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-01-26
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Angiogenesis Connexin43 Connexins Endothelial progenitor cell Cancer Research Biomedicine general Cell Biology Cardiology Ophthalmology Oncology
Content Type	Text
Resource Type	Article
Subject	Physiology Clinical Biochemistry Cancer Research

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