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| Content Provider | Springer Nature Link |
|---|---|
| Author | Moore, Scott M. Zhang, Hua Maeda, buyo Doerschuk, Claire M. Faber, James E. |
| Copyright Year | 2015 |
| Abstract | Collaterals lessen tissue injury in occlusive disease. However, aging causes progressive decline in their number and smaller diameters in those that remain (collateral rarefaction), beginning at 16 months of age in mice (i.e., middle age), and worse ischemic injury—effects that are accelerated in even 3-month-old eNOS−/− mice. These findings have found indirect support in recent human studies.We sought to determine whether other cardiovascular risk factors (CVRFs) associated with endothelial dysfunction cause collateral rarefaction, investigate possible mechanisms, and test strategies for prevention.Mice with nine different models of CVRFs of 4–12 months of age were assessed for number and diameter of native collaterals in skeletal muscle and brain and for collateral-dependent perfusion and ischemic injury after arterial occlusion. Hypertension caused collateral rarefaction whose severity increased with duration and level of hypertension, accompanied by greater hindlimb ischemia and cerebral infarct volume. Chronic treatment of wild-type mice with l-N G-nitro-arginine methylester caused similar rarefaction and worse ischemic injury which were not prevented by lowering arterial pressure with hydralazine. Metabolic syndrome, hypercholesterolemia, diabetes mellitus, and obesity also caused collateral rarefaction. Neither chronic statin treatment nor exercise training lessened hypertension-induced rarefaction.Chronic CVRF presence caused collateral rarefaction and worse ischemic injury, even at relatively young ages. Rarefaction was associated with increased proliferation rate of collateral endothelial cells, effects that may promote accelerated endothelial cell senescence. |
| Starting Page | 265 |
| Ending Page | 281 |
| Page Count | 17 |
| File Format | |
| ISSN | 09696970 |
| Journal | Angiogenesis |
| Volume Number | 18 |
| Issue Number | 3 |
| e-ISSN | 15737209 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2015-04-11 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Collateral circulation Cardiovascular risk factors Endothelial dysfunction Hypertension Diabetes mellitus Metabolic syndrome Hyperlipidemia Obesity Cerebral circulation Ischemic stroke Peripheral vascular disease Cancer Research Biomedicine general Cell Biology Cardiology Ophthalmology Oncology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Clinical Biochemistry Cancer Research |
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