NDLI: Visualizing vascular permeability and lymphatic drainage using labeled serum albumin

Content Provider	Springer Nature Link
Author	Vandoorne, Katrien Addadi, Yoseph Neeman, Michal
Copyright Year	2010
Abstract	During the early stages of angiogenesis, following stimulation of endothelial cells by vascular endothelial growth factor (VEGF), the vascular wall is breached, allowing high molecular weight proteins to leak from the vessels to the interstitial space. This hallmark of angiogenesis results in deposition of a provisional matrix, elevation of the interstitial pressure and induction of interstitial convection. Albumin, the major plasma protein appears to be an innocent bystander that is significantly affected by these changes, and thus can be used as a biomarker for vascular permeability associated with angiogenesis. Traditionally, albumin leak in superficial organs was followed by colorimetry or morphometry with the use of albumin binding vital dyes. Over the last years, the introduction of tagged-albumin that can be detected by various imaging methods, such as magnetic resonance imaging and positron emission tomography, opened new possibilities for quantitative three dimension dynamic analysis of permeability in any organ. Using these tools it is now possible to follow not only vascular permeability, but also interstitial convection and lymphatic drain. Active uptake of tagged albumin by caveolae-mediated endocytosis opens the possibility for using labeled albumin for vital staining of cells and cell tracking. This approach was used for monitoring recruitment of perivascular stroma fibroblasts associated with tumor angiogenesis.
Starting Page	75
Ending Page	85
Page Count	11
File Format	PDF
ISSN	09696970
Journal	Angiogenesis
Volume Number	13
Issue Number	2
e-ISSN	15737209
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-05-29
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Vascular permeability Interstitial convection Lymphatic drain Albumin VEGF Imaging Cell tracking Oncology Ophthalmology Cardiology Cell Biology Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Physiology Clinical Biochemistry Cancer Research

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