NDLI: Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells

Content Provider	Springer Nature Link
Author	Kesler, Cristina T. Kuo, Angera H. Wong, Hon Kit Masuck, David J. Shah, Jennifer L. Kozak, Kevin R. Held, Kathryn D. Padera, Timothy P.
Copyright Year	2013
Abstract	Radiation therapy after lymph node dissection increases the risk of developing painful and incurable lymphedema in breast cancer patients. Lymphedema occurs when lymphatic vessels become unable to maintain proper fluid balance. The sensitivity of lymphatic endothelial cells (LECs) to ionizing radiation has not been reported to date. Here, the radiosensitivity of LECs in vitro has been determined using clonogenic survival assays. The ability of various growth factors to alter LEC radiosensitivity was also examined. Vascular endothelial growth factor (VEGF)-C enhanced radiosensitivity when LECs were treated prior to radiation. VEGF-C-treated LECs exhibited higher levels of entry into the cell cycle at the time of radiation, with a greater number of cells in the S and G2/M phases. These LECs showed higher levels of γH2A.X—an indicator of DNA damage—after radiation. VEGF-C did not increase cell death as a result of radiation. Instead, it increased the relative number of quiescent LECs. These data suggest that abundant VEGF-C or lymphangiogenesis may predispose patients to radiation-induced lymphedema by impairing lymphatic vessel repair through induction of LEC quiescence.
Starting Page	419
Ending Page	427
Page Count	9
File Format	PDF
ISSN	09696970
Journal	Angiogenesis
Volume Number	17
Issue Number	2
e-ISSN	15737209
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-11-08
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lymphedema Lymphangiogenesis Radiotherapy Lymphatic endothelium VEGF-C Cancer Research Biomedicine general Cell Biology Cardiology Ophthalmology Oncology
Content Type	Text
Resource Type	Article
Subject	Physiology Clinical Biochemistry Cancer Research

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