NDLI: Wall Stress Reduction in Abdominal Aortic Aneurysms as a Result of Polymeric Endoaortic Paving

Content Provider	Springer Nature Link
Author	Ashton, John H. Ayyalasomayajula, Avinash Simon, Bruce R. Vande Geest, Jonathan P.
Copyright Year	2011
Abstract	Polymeric endoaortic paving (PEAP) may improve endovascular repair of abdominal aortic aneurysms (AAA) since it has the potential to treat patients with complex AAA geometries while reducing the incidence of migration and endoleak. Polycaprolactone (PCL)/polyurethane (PU) blends are proposed as PEAP materials due to their range of mechanical properties, thermoformability, and resistance to biodegradation. In this study, the reduction in AAA wall stress that can be achieved using PEAP was estimated and compared to that resulting from stent-grafts. This was accomplished by mechanically modeling the anisotropic response of PCL/PU blends and implementing these results into finite element model (FEM) simulations. We found that at the maximum diameter of the AAA, the 50/50 and 10/90 PCL/PU blends reduced wall stress by 99 and 98%, respectively, while a stent-graft reduced wall stress by 99%. Our results also show that wall stress reduction increases with increasing PEAP thickness and PCL content in the blend ratio. These results indicate that PEAP can reduce AAA wall stress as effectively as a stent-graft. As such, we propose that PEAP may provide an improved treatment alternative for AAA, since many of the limitations of stent-grafts have the potential to be solved using this approach.
Starting Page	1680
Ending Page	1689
Page Count	10
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	39
Issue Number	6
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2011-02-25
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	AAA Endovascular repair Stent-graft Porohyperelasticity Finite element Polycaprolactone Polyurethane Anisotropy Biophysics and Biological Physics Mechanics Biochemistry Biomedical Engineering Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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