NDLI: Detecting Alterations in Pulmonary Airway Development with Airway-by-Airway Comparison

Content Provider	Springer Nature Link
Author	Lee, DongYoub Willits, Neil Wexler, Anthony S.
Copyright Year	2011
Abstract	Neonatal and postnatal exposures to air pollutants have adverse effects on lung development resulting in airway structure changes. Usually, generation-averaged analysis of airway geometric parameters is employed to differentiate between pulmonary airway trees. However, this method is limited, especially for monopodial branching trees such as in rat airways, because both quite proximal and less proximal airways that have very different structure and function may be in the same generation. To avoid limitations inherent in generation averaging, we developed a method that compares two trees airway-by-airway using micro CT image data from rat lungs. This computerized technique (1) identifies the geometry and architecture of the conducting airways from CT images, (2) extracts the main tree, (3) associates paired airways from the two different trees, and (4) develops summary statistics on the degree of similarity between populations of animals. By comparing the trees airway-by-airway, we found that the variance in airway length of the group exposed to diffusion flame particles (DFP) is significantly larger than the group raised in filtered air (FA). This method also found that rotation angle of the DFP group is significantly larger than FA, which is not as certain in the generation-based analysis. We suggest that airway-by-airway analysis complements generation-based averaging for detecting airway alterations.
Starting Page	1805
Ending Page	1814
Page Count	10
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	39
Issue Number	6
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2011-02-23
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Development disruption Pulmonary airways CT image Rat lungs Airway-by-airway comparison Diffusion flame particles Biophysics and Biological Physics Mechanics Biochemistry Biomedical Engineering Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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