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| Content Provider | Springer Nature Link |
|---|---|
| Author | Bia, Daniel Zócalo, Yanina Armenta, Ricardo Laza, Sebastián Pérez, Héctor Craiem, Damián Saldías, María Álvarez, Inés |
| Copyright Year | 2009 |
| Abstract | Native vessels–grafts biomechanical mismatch (BM) is related to graft failure. The BM could be reduced using human cryopreserved/defrosted arteries (cryografts), but post-thaw cryografts’ recovery could be associated with an impaired biomechanical behavior. In vitro, we demonstrated that our cryopreservation methods do not affect arteries’ biomechanics, but only post-implant studies would allow determining the cryografts’ biomechanical performance. Aim To characterize the biomechanical properties of implanted cryografts, and to compare them with cryografts pre-implant, recipients’ native arteries, and arteries from subjects with characteristics similar to those of the recipients and multiorgan donors (MOD) whose arteries were cryopreserved. Methods Native femoral arteries anastomosed to cryografts, implanted cryografts, and arteries from subjects, recipient-like and MOD-like, were studied. In vitro (pre-implant cryografts) and in vivo non-invasive studies were performed. Arterial pressure, diameter, and wall thickness were obtained to quantify local and regional biomechanical parameters, and to evaluate the arterial remodeling. Conclusion Implanted cryografts were remodeled, with an increased wall thickness, wall-to-lumen ratio, and wall cross-sectional area. The proximal–distal gradual transition in stiffness remained unchanged. Implanted cryografts were stiffer than MOD-like arteries, but more compliant than recipients’ arteries. The cryografts–native arteries biomechanical differences were lesser than those described for venous grafts or expanded polytetrafluoroethylene. |
| Starting Page | 1273 |
| Ending Page | 1286 |
| Page Count | 14 |
| File Format | |
| ISSN | 00906964 |
| Journal | Annals of Biomedical Engineering |
| Volume Number | 37 |
| Issue Number | 7 |
| e-ISSN | 15739686 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2009-04-21 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Arterial stiffness Arterial remodeling Biomechanical mismatch B-mode echography Cryopreserved arterial homografts Elasticity Intima-media thickness Non-invasive evaluation Pulse wave velocity Biochemistry Mechanics Biophysics/Biomedical Physics Biomedical Engineering Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomedical Engineering |
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