NDLI: Cylinders vs. Spheres: Biofluid Shear Thinning in Driven Nanoparticle Transport

Content Provider	Springer Nature Link
Author	Cribb, Jeremy A. Meehan, Timothy D. Shah, Sheel M. Skinner, Kwan Superfine, Richard
Copyright Year	2010
Abstract	Increasingly, the research community applies magnetophoresis to micro and nanoscale particles for drug delivery applications and the nanoscale rheological characterization of complex biological materials. Of particular interest is the design and transport of these magnetic particles through entangled polymeric fluids commonly found in biological systems. We report the magnetophoretic transport of spherical and rod-shaped particles through viscoelastic, entangled solutions using lambda-phage DNA (λ-DNA) as a model system. In order to understand and predict the observed phenomena, we fully characterize three fundamental components: the magnetic field and field gradient, the shape and magnetic properties of the probe particles, and the macroscopic rheology of the solution. Particle velocities obtained in Newtonian solutions correspond to macroscale rheology, with forces calculated via Stokes Law. In λ-DNA solutions, nanorod velocities are 100 times larger than predicted by measured zero-shear viscosity. These results are consistent with particles experiencing transport through a shear thinning fluid, indicating magnetically driven transport in shear thinning may be especially effective and favor narrow diameter, high aspect ratio particles. A complete framework for designing single-particle magnetic-based delivery systems results when we combine a quantified magnetic system with qualified particles embedded in a characterized viscoelastic medium.
Starting Page	3311
Ending Page	3322
Page Count	12
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	38
Issue Number	11
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2010-06-23
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Shape effects Drug delivery Nanorods Nanowires Microrheology DNA Magnetic bead rheology Biochemistry Mechanics Biophysics and Biological Physics Biomedical Engineering Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cylinders vs. Spheres: Biofluid Shear Thinning in Driven Nanoparticle Transport

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

Controlled Release in Transdermal Pressure Sensitive Adhesives using Organosilicate Nanocomposites

2011 Rita Schaffer Lecture: Nanoparticles for Intracellular Nucleic Acid Delivery

A Modification of Murray's Law for Shear-Thinning Rheology

Experimental and Numerical Models of Three-Dimensional Gravity-Driven Flow of Shear-Thinning Polymer Solutions Used in Vaginal Delivery of Microbicides

Nanoparticle Deposition onto Biofilms

Drug delivery

Characterization of Superparamagnetic Nanoparticle Interactions with Extracellular Matrix in an in Vitro System

Cylinders vs. Spheres: Biofluid Shear Thinning in Driven Nanoparticle Transport

Similar Documents

Cylinders vs. Spheres: Biofluid Shear Thinning in Driven Nanoparticle Transport

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

Controlled Release in Transdermal Pressure Sensitive Adhesives using Organosilicate Nanocomposites

2011 Rita Schaffer Lecture: Nanoparticles for Intracellular Nucleic Acid Delivery

A Modification of Murray's Law for Shear-Thinning Rheology

Experimental and Numerical Models of Three-Dimensional Gravity-Driven Flow of Shear-Thinning Polymer Solutions Used in Vaginal Delivery of Microbicides

Nanoparticle Deposition onto Biofilms

Drug delivery

Characterization of Superparamagnetic Nanoparticle Interactions with Extracellular Matrix in an in Vitro System

Cylinders vs. Spheres: Biofluid Shear Thinning in Driven Nanoparticle Transport