NDLI: Distribution of Capillary Transit Times in Isolated Lungs of Oxygen-Tolerant Rats

Content Provider	Springer Nature Link
Author	Ramakrishna, Madhavi Gan, Zhuohui Clough, Anne V. Molthen, Robert C. Roerig, David L. Audi, Said H.
Copyright Year	2010
Abstract	Rats pre-exposed to 85% O2 for 5–7 days tolerate the otherwise lethal effects of 100% O2. The objective was to evaluate the effect of rat exposure to 85% O2 for 7 days on lung capillary mean transit time $$ (\bar{t}_{\text{c}} ) $$ and distribution of capillary transit times (h c(t)). This information is important for subsequent evaluation of the effect of this hyperoxia model on the redox metabolic functions of the pulmonary capillary endothelium. The venous concentration vs. time outflow curves of fluorescein isothiocyanate labeled dextran (FITC-dex), an intravascular indicator, and coenzyme Q1 hydroquinone (CoQ1H2), a compound which rapidly equilibrates between blood and tissue on passage through the pulmonary circulation, were measured following their bolus injection into the pulmonary artery of isolated perfused lungs from rats exposed to room air (normoxic) or 85% O2 for 7 days (hyperoxic). The moments (mean transit time and variance) of the measured FITC-dex and CoQ1H2 outflow curves were determined for each lung, and were then used in a mathematical model [Audi et al. J. Appl. Physiol. 77: 332–351, 1994] to estimate $$ \bar{t}_{\text{c}} $$ and the relative dispersion (RDc) of h c(t). Data analysis reveals that exposure to hyperoxia decreases lung $$ \bar{t}_{\text{c}} $$ by 42% and increases RDc, a measure h c(t) heterogeneity, by 40%.
Starting Page	3449
Ending Page	3465
Page Count	17
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	38
Issue Number	11
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2010-06-15
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Perfusion heterogeneity Hyperoxia Coenzyme Q1 Multiple indicator dilution Flow-limited indicators Angiotensin converting enzyme Biochemistry Mechanics Biophysics and Biological Physics Biomedical Engineering Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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