NDLI: MEG Connectivity Analysis in Patients with Alzheimer’s Disease Using Cross Mutual Information and Spectral Coherence

Content Provider	Springer Nature Link
Author	Alonso, Joan Francesc Poza, Jesús Mañanas, Miguel Ángel Romero, Sergio Fernández, Alberto Hornero, Roberto
Copyright Year	2010
Abstract	Alzheimer’s disease (AD) is an irreversible brain disorder which represents the most common form of dementia in western countries. An early and accurate diagnosis of AD would enable to develop new strategies for managing the disease; however, nowadays there is no single test that can accurately predict the development of AD. In this sense, only a few studies have focused on the magnetoencephalographic (MEG) AD connectivity patterns. This study compares brain connectivity in terms of linear and nonlinear couplings by means of spectral coherence and cross mutual information function (CMIF), respectively. The variables defined from these functions provide statistically significant differences (p < 0.05) between AD patients and control subjects, especially the variables obtained from CMIF. The results suggest that AD is characterized by both decreases and increases of functional couplings in different frequency bands as well as by an increase in regularity, that is, more evident statistical deterministic relationships in AD patients’ MEG connectivity. The significant differences obtained indicate that AD could disturb brain interactions causing abnormal brain connectivity and operation. Furthermore, the combination of coherence and CMIF features to perform a diagnostic test based on logistic regression improved the tests based on individual variables for its robustness.
Starting Page	524
Ending Page	536
Page Count	13
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	39
Issue Number	1
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2010-09-08
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Alzheimer’s disease Magnetoencephalogram Cross mutual information function (CMIF) Magnitude squared coherence (MSC) Biochemistry Mechanics Biophysics and Biological Physics Biomedical Engineering Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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