NDLI: Hemodynamics of Stent Implantation Procedures in Coronary Bifurcations: An In Vitro Study

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Hemodynamics of Stent Implantation Procedures in Coronary Bifurcations: An In Vitro Study

Content Provider	Springer Nature Link
Author	Brindise, Melissa C. Chiastra, Claudio Burzotta, Francesco Migliavacca, Francesco Vlachos, Pavlos P.
Copyright Year	2016
Abstract	Stent implantation in coronary bifurcations presents unique challenges and currently there is no universally accepted stent deployment approach. Despite clinical and computational studies, the effect of each stent implantation method on the coronary artery hemodynamics is not well understood. In this study the hemodynamics of stented coronary bifurcations under pulsatile flow conditions were investigated experimentally. Three implantation methods, provisional side branch (PSB), culotte (CUL), and crush (CRU), were investigated using time-resolved particle image velocimetry to measure the velocity fields. Subsequently, hemodynamic parameters including wall shear stress, oscillatory shear index (OSI), and relative residence time (RRT) were calculated. The pressure field through the vessel was non-invasively quantified and pressure wave speeds were computed. The effects of each stented case were evaluated and compared against an un-stented case. CRU provided the lowest compliance mismatch, but demonstrated detrimental stent interactions. PSB, the clinically preferred method, and CUL maintained many normal flow conditions. However, PSB provided about a 300% increase in both OSI and RRT. CUL yielded a 10 and 85% increase in OSI and RRT, respectively. The results of this study support the concept that different bifurcation stenting techniques result in hemodynamic environments that deviate from that of un-stented bifurcations, to varying degrees.
Starting Page	542
Ending Page	553
Page Count	12
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	45
Issue Number	3
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2016-07-26
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Coronary bifurcation Stenting technique Experimental fluid dynamics Particle image velocimetry Provisional side branch Culotte Crush Biomedicine Biomedical Engineering Biological and Medical Physics, Biophysics Classical Mechanics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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