NDLI: Non-invasive Model-Based Assessment of Passive Left-Ventricular Myocardial Stiffness in Healthy Subjects and in Patients with Non-ischemic Dilated Cardiomyopathy

Please wait, while we are loading the content...

Non-invasive Model-Based Assessment of Passive Left-Ventricular Myocardial Stiffness in Healthy Subjects and in Patients with Non-ischemic Dilated Cardiomyopathy

Fluid-Structure Interaction Analysis of Ruptured Mitral Chordae Tendineae

Estrogen Preserves Pulsatile Pulmonary Arterial Hemodynamics in Pulmonary Arterial Hypertension

Hemodynamic Influence on Smooth Muscle Cell Kinetics and Phenotype During Early Vein Graft Adaptation

Dynamic Response and Residual Helmet Liner Crush Using Cadaver Heads and Standard Headforms

Finite Element-Derived Surrogate Models of Locked Plate Fracture Fixation Biomechanics

Mechanically Stable Intraspinal Microstimulation Implants for Human Translation

Automated Gait Analysis Through Hues and Areas (AGATHA): A Method to Characterize the Spatiotemporal Pattern of Rat Gait

Postural Control of Elderly Adults on Inclined Surfaces

Design Considerations of a Fiber Optic Pressure Sensor Protective Housing for Intramuscular Pressure Measurements

In Silico and In Vivo Experiments Reveal M-CSF Injections Accelerate Regeneration Following Muscle Laceration

Effects of Biowastes Released by Mechanically Damaged Muscle Cells on the Propagation of Deep Tissue Injury: A Multiphysics Study

Effect of Anconeus Muscle Blocking on Elbow Kinematics: Electromyographic, Inertial Sensors and Finite Element Study

Dependence of Muscle Moment Arms on In Vivo Three-Dimensional Kinematics of the Knee

Determination and Finite Element Validation of the WYPIWYG Strain Energy of Superficial Fascia from Experimental Data

In Vivo Contrast-Enhanced Cone Beam CT Provides Quantitative Information on Articular Cartilage and Subchondral Bone

Effects of Iron on Physical and Mechanical Properties, and Osteoblast Cell Interaction in β-Tricalcium Phosphate

Finite Element Model and Validation of Nasal Tip Deformation

Obstructive Sleep Apnea Screening and Airway Structure Characterization During Wakefulness Using Tracheal Breathing Sounds

Erratum to: Obstructive Sleep Apnea Screening and Airway Structure Characterization During Wakefulness Using Tracheal Breathing Sounds

Annals of Biomedical Engineering : Volume 45, Issue 2, February 2017

Annals of Biomedical Engineering : Volume 45, Issue 1, January 2017

Annals of Biomedical Engineering : Volume 44

Annals of Biomedical Engineering : Volume 43

Annals of Biomedical Engineering : Volume 42

Annals of Biomedical Engineering : Volume 41

Annals of Biomedical Engineering : Volume 40

Annals of Biomedical Engineering : Volume 39

Annals of Biomedical Engineering : Volume 38

Annals of Biomedical Engineering : Volume 37

Annals of Biomedical Engineering : Volume 36

Annals of Biomedical Engineering : Volume 35

Annals of Biomedical Engineering : Volume 34

Annals of Biomedical Engineering : Volume 33

Annals of Biomedical Engineering : Volume 32

Annals of Biomedical Engineering : Volume 31

Annals of Biomedical Engineering : Volume 30

Annals of Biomedical Engineering : Volume 29

Annals of Biomedical Engineering : Volume 28

Annals of Biomedical Engineering : Volume 27

Annals of Biomedical Engineering : Volume 26

Annals of Biomedical Engineering : Volume 25

Non-invasive Model-Based Assessment of Passive Left-Ventricular Myocardial Stiffness in Healthy Subjects and in Patients with Non-ischemic Dilated Cardiomyopathy

Content Provider	Springer Nature Link
Author	Hadjicharalambous, Myrianthi Asner, Liya Chabiniok, Radomir Sammut, Eva Wong, James Peressutti, Devis Kerfoot, Eric King, Andrew Lee, Jack Razavi, Reza Smith, Nicolas Carr White, Gerald rdsletten, David
Copyright Year	2016
Abstract	Patient-specific modelling has emerged as a tool for studying heart function, demonstrating the potential to provide non-invasive estimates of tissue passive stiffness. However, reliable use of model-derived stiffness requires sufficient model accuracy and unique estimation of model parameters. In this paper we present personalised models of cardiac mechanics, focusing on improving model accuracy, while ensuring unique parametrisation. The influence of principal model uncertainties on accuracy and parameter identifiability was systematically assessed in a group of patients with dilated cardiomyopathy ( $$n=3$$ ) and healthy volunteers ( $$n=5$$ ). For all cases, we examined three circumferentially symmetric fibre distributions and two epicardial boundary conditions. Our results demonstrated the ability of data-derived boundary conditions to improve model accuracy and highlighted the influence of the assumed fibre distribution on both model fidelity and stiffness estimates. The model personalisation pipeline—based strictly on non-invasive data—produced unique parameter estimates and satisfactory model errors for all cases, supporting the selected model assumptions. The thorough analysis performed enabled the comparison of passive parameters between volunteers and dilated cardiomyopathy patients, illustrating elevated stiffness in diseased hearts.
Starting Page	605
Ending Page	618
Page Count	14
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	45
Issue Number	3
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2016-09-07
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Stiffness Myocardium Patient-specific modelling Model uncertainties Parameter uniqueness Biomedicine Biomedical Engineering Biological and Medical Physics, Biophysics Classical Mechanics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Non-invasive Model-Based Assessment of Passive Left-Ventricular Myocardial Stiffness in Healthy Subjects and in Patients with Non-ischemic Dilated Cardiomyopathy

Non-invasive Model-Based Assessment of Passive Left-Ventricular Myocardial Stiffness in Healthy Subjects and in Patients with Non-ischemic Dilated Cardiomyopathy

Assessment of Passive Left-Ventricular Myocardial Stiffness in Healthy Subjects and in Patients with Non-ischemic Dilated Cardiomyopathy. Annals

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy (2004).

Native left ventricular myocardial T1 spatial heterogeneity in non-ischemic dilated cardiomyopathy

MAGGIC Risk Model Predicts Adverse Events and Left Ventricular Remodeling in Non-Ischemic Dilated Cardiomyopathy

Improved aorto-ventricular matching in ischemic dilated cardiomyopathy patients after surgical ventricular restoration.

Myocardial deformation by speckle tracking in severe dilated cardiomyopathy.

The effect of myocardial fibrosis on left ventricular torsion and twist in patients with non-ischemic dilated cardiomyopathy.

Non-invasive Model-Based Assessment of Passive Left-Ventricular Myocardial Stiffness in Healthy Subjects and in Patients with Non-ischemic Dilated Cardiomyopathy

Similar Documents

Non-invasive Model-Based Assessment of Passive Left-Ventricular Myocardial Stiffness in Healthy Subjects and in Patients with Non-ischemic Dilated Cardiomyopathy

Non-invasive Model-Based Assessment of Passive Left-Ventricular Myocardial Stiffness in Healthy Subjects and in Patients with Non-ischemic Dilated Cardiomyopathy

Assessment of Passive Left-Ventricular Myocardial Stiffness in Healthy Subjects and in Patients with Non-ischemic Dilated Cardiomyopathy. Annals

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy (2004).

Native left ventricular myocardial T1 spatial heterogeneity in non-ischemic dilated cardiomyopathy

MAGGIC Risk Model Predicts Adverse Events and Left Ventricular Remodeling in Non-Ischemic Dilated Cardiomyopathy

Improved aorto-ventricular matching in ischemic dilated cardiomyopathy patients after surgical ventricular restoration.

Myocardial deformation by speckle tracking in severe dilated cardiomyopathy.

The effect of myocardial fibrosis on left ventricular torsion and twist in patients with non-ischemic dilated cardiomyopathy.

Non-invasive Model-Based Assessment of Passive Left-Ventricular Myocardial Stiffness in Healthy Subjects and in Patients with Non-ischemic Dilated Cardiomyopathy