NDLI: A Novel Spatiotemporal Analysis of Peri-Ictal Spiking to Probe the Relation of Spikes and Seizures in Epilepsy

Content Provider	Springer Nature Link
Author	Krishnan, Balu Vlachos, Ioannis Faith, Aaron Mullane, Steven Williams, Korwyn Alexopoulos, Andreas Iasemidis, Leonidas
Copyright Year	2014
Abstract	The relation between epileptic spikes and seizures is an important but still unresolved question in epilepsy research. Preclinical and clinical studies have produced inconclusive results on the causality or even on the existence of such a relation. We set to investigate this relation taking in consideration seizure severity and spatial extent of spike rate. We developed a novel automated spike detection algorithm based on morphological filtering techniques and then tested the hypothesis that there is a pre-ictal increase and post-ictal decrease of the spatial extent of spike rate. Peri-ictal (around seizures) spikes were detected from intracranial EEG recordings in 5 patients with temporal lobe epilepsy. The 94 recorded seizures were classified into two classes, based on the percentage of brain sites having higher or lower rate of spikes in the pre-ictal compared to post-ictal periods, with a classification accuracy of 87.4%. This seizure classification showed that seizures with increased pre-ictal spike rate and spatial extent compared to the post-ictal period were mostly (83%) clinical seizures, whereas no such statistically significant (α = 0.05) increase was observed peri-ictally in 93% of sub-clinical seizures. These consistent across patients results show the existence of a causal relation between spikes and clinical seizures, and imply resetting of the preceding spiking process by clinical seizures.
Starting Page	1606
Ending Page	1617
Page Count	12
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	42
Issue Number	8
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2014-04-17
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Morphological filter Spatiotemporal analysis EEG Spikes Seizures Ictogenesis Epilepsy Biomedicine general Biomedical Engineering Biophysics and Biological Physics Mechanics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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