NDLI: Simulated Two-dimensional Red Blood Cell Motion, Deformation, and Partitioning in Microvessel Bifurcations

Content Provider	Springer Nature Link
Author	Barber, Jared O. Alberding, Jonathan P. Restrepo, Juan M. Secomb, Timothy W.
Copyright Year	2008
Abstract	Movement, deformation, and partitioning of mammalian red blood cells (RBCs) in diverging microvessel bifurcations are simulated using a two-dimensional, flexible-particle model. A set of viscoelastic elements represents the RBC membrane and the cytoplasm. Motion of isolated cells is considered, neglecting cell-to-cell interactions. Center-of-mass trajectories deviate from background flow streamlines due to migration of flexible cells towards the mother vessel centerline upstream of the bifurcation and due to flow perturbations caused by cell obstruction in the neighborhood of the bifurcation. RBC partitioning in the bifurcation is predicted by determining the RBC fraction entering each branch, for a given partition of total flow and for a given upstream distribution of RBCs. Typically, RBCs preferentially enter the higher-flow branch, leading to unequal discharge hematocrits in the downstream branches. This effect is increased by migration toward the centerline but decreased by the effects of obstruction. It is stronger for flexible cells than for rigid circular particles of corresponding size, and decreases with increasing parent vessel diameter. For unequally sized daughter vessels, partitioning is asymmetric, with RBCs tending to enter the smaller vessel. Partitioning is not significantly affected by branching angles. Model predictions are consistent with previous experimental results.
Starting Page	1690
Ending Page	1698
Page Count	9
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	36
Issue Number	10
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2008-08-07
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Microvessel Bifurcation Erythrocyte mechanics Capillary flow Phase separation Biochemistry Mechanics Biophysics/Biomedical Physics Biomedical Engineering Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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