NDLI: Nonlinear model for capillary-tissue oxygen transport and metabolism

Content Provider	Springer Nature Link
Author	Li, Zheng Yipintsoi, Tada Bassingthwaighte, James B.
Copyright Year	1997
Abstract	Oxygen consumption in small tissue regions cannot be measured directly, but assessment of oxygen transport and metabolism at the regional level is possible with imaging techniques using tracer15O-oxygen for positron emission tomography. On the premise that mathematical modeling of tracer kinetics is the key to the interpretation of regional concentration-time curves, an axially-distributed capillary-tissue model was developed that accounts for oxygen convection in red blood cells and plasma, nonlinear binding to hemoglobin and myoglobin transmembrane transport among red blood cells, plasma, interstitial fluid and parenchymal cells, axial dispersion, transformation to water in the tissue, and carriage of the reaction product into venous effluent. Computational speed was maximized to make the model useful for routine analysis of experimental data. The steady-state solution of a parent model for tracer oxygen and tracer water. The set of models provides estimates of oxygen consumption, extraction, and venouspO2 by fitting model solutions to experimental tracer curves of the regional tissue content or venous outflow. The estimate myocardial oxygen consumption for the whole heart was in good agreement with that measured directly by the Fick method and was relatively insensitive to noise. General features incorporated in the model make it widely applicable to estimating oxygen consumption in other organs from data obtained by external detection methods such as positron emission tomography.
Starting Page	604
Ending Page	619
Page Count	16
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	25
Issue Number	4
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	1997-01-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nonlinear modeling Convection Diffusion Permeation Binding Metabolic reaction Heat Myocardial blood flow Heterogeneity PET Biomedicine general Biochemistry Mechanics Biophysics/Biomedical Physics Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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