NDLI: A Topographically Modified Substrate-Embedded MEA for Directed Myotube Formation at Electrode Contact Sites

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A Topographically Modified Substrate-Embedded MEA for Directed Myotube Formation at Electrode Contact Sites

Content Provider	Springer Nature Link
Author	Langhammer, Christopher G. Kutzing, Melinda K. Luo, Vincent Zahn, Jeffrey D. Firestein, Bonnie L.
Copyright Year	2012
Abstract	Myoblast fusion into functionally distinct myotubes, and their subsequent integration with the nervous system, is a poorly understood phenomenon with important applications in basic science research, skeletal muscle tissue engineering, and cell-based biosensor development. We have previously demonstrated the ability of microelectrode arrays (MEAs) to record the extracellular action potentials of myotubes, and we have shown that this information reveals the presence of multiple, electrophysiologically independent myotubes even in unstructured cultures where there is extensive physical contact between cells (Langhammer et al., Biotechnol Prog 27:891–895, 2011). In this paper, we explore the ability of microscale topographical trenches to guide the myoblast alignment and fusion processes and use our findings to create a substrate-embedded MEA containing topographical trenches that are able to direct myotube contractility to specific locations. By combining substrate-embedded MEA technology with topographical patterns, we have developed a lab-on-a-chip test bed for the non-invasive examination of myotubes.
Starting Page	408
Ending Page	420
Page Count	13
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	41
Issue Number	2
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2012-09-07
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Microelectrode array Myoblast alignment Myoblast fusion Topographical trenches Substrate embedding Biomedicine general Biomedical Engineering Biophysics and Biological Physics Mechanics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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