NDLI: Implantable thin-film porous microelectrode array (P-MEA) for electrical stimulation of engineered cardiac tissues

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Implantable thin-film porous microelectrode array (P-MEA) for electrical stimulation of engineered cardiac tissues

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Implantable thin-film porous microelectrode array (P-MEA) for electrical stimulation of engineered cardiac tissues

Content Provider	Springer Nature Link
Author	Trada, Hiren V. Vendra, Venkat Tinney, Joseph P. Yuan, Fangping Jackson, Douglas J. Walsh, Kevin M. Keller, Bradley B.
Copyright Year	2015
Abstract	We have designed, fabricated, and validated a novel porous, multielectrode array (P-MEA) device capable of low-voltage electrical stimulation of engineered cardiac tissues (ECTs). The primary advantage of this device is the ability to successfully function at a very low voltage thus minimizing any undesirable oxidative by-products in the culture environment or cell injury. Major features of our P-MEA include dimensions of 10 mm width and 82 mm length, four arms to allow movement of the individual pads within ECTs, each embedded electrode arm incorporates eight 100 µm×200 µm rectangular pores surrounding a 950 µm×340 µm exposed electrode, large pads on either side of the porous embedded device to function as current return electrodes, suture holes to aid in vivo suturing and stabilization, and an eight electrode connector pads. Average thickness of the Ni/Au electrodes was 20 nm of nickel and 400 nm of gold, an average electrode film thickness of 0.4 µm, and a double polyimide layer thickness of 16 µm. Electrode resistance ranged from 69.45 O to 78.52 O. Electrochemical impedance spectroscopy confirmed that the P-MEA operates in the 0.01 V to 1.0 V range with favorable charge transfer characteristics. Proof of principle experiments confirmed the ability of the P-MEA to effectively embed within ECT and electrically stimulate ECT during chronic, in vitro culture. Histology imaging shows that the embedding of the device has no adverse effects on the ECT and the cardiomyocytes are aligned within the tissue. Experiments are ongoing to evaluate the role of electrical stimulation on the maturation and function of ECTs.
Starting Page	85
Ending Page	94
Page Count	10
File Format	PDF
ISSN	19760280
Journal	BioChip Journal
Volume Number	9
Issue Number	2
e-ISSN	20927843
Language	English
Publisher	The Korean BioChip Society (KBCS)
Publisher Date	2015-03-18
Publisher Place	Seoul
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cardiac pacing Heart failure Micro electrode array Thin film Tissue engineering Biotechnology Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Bioengineering Biomedical Engineering Electrical and Electronic Engineering Biotechnology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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