NDLI: Serpentine and leading-edge capillary pumps for microfluidic capillary systems

Content Provider	Springer Nature Link
Author	Safavieh, Roozbeh Tamayol, Ali Juncker, David
Copyright Year	2014
Abstract	Microfluidic capillary systems operate using capillary forces only and require capillary pumps (CPs) to transport, regulate, and meter the flow of small quantity of liquids. Common CP architectures include arrays of posts or tree-like branched conduits that offer many parallel flow paths. However, both designs are susceptible to bubble entrapment and consequently variation in the metered volume. Here, we present two novel CP architectures that deterministically guide the filling front along rows while preventing the entrapment of bubbles using variable gap sizes between posts. The first CP (serpentine pump) guides the filling front following a serpentine path, and the second one (leading-edge pump) directs the liquid along one edge of the CP from where liquid fills the pump row-by-row. We varied the angle of the rows with respect to the pump perimeter and observed filling with minimal variation in pumping pressure and volumetric flow rate, confirming the robustness of this design. In the case of serpentine CP, the flow resistance for filling the first row is high and then decreases as subsequent rows are filled and many parallel flow paths are formed. In the leading-edge pump, parallel flow paths are formed almost immediately, and hence, no spike in flow resistance is observed; however, there is a higher tendency of the liquid for skipping a row, requiring more stringent fabrication tolerances. The flow rate within a single CP was adjusted by tuning the gap size between the microposts within the CP so as to create a gradient in pressure and flow rate. In summary, CP with deterministic guidance of the filling front enables precise and robust control of flow rate and volume.
Starting Page	357
Ending Page	366
Page Count	10
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	18
Issue Number	3
e-ISSN	16134990
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-07-17
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Capillary flow Passive pumping Microfluidics Pore network modeling Point-of-care Engineering Fluid Dynamics Biomedical Engineering Analytical Chemistry Nanotechnology and Microengineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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