NDLI: Differential behavior of EGFR-overexpressing cancer cells through aptamer-functionalized micropores

Content Provider	Springer Nature Link
Author	Bellah, Md. Motasim Iqbal, Samir M. Kim, Young Tae
Copyright Year	2014
Abstract	Circulating tumor cell detection is one important avenue for early cancer diagnosis. A differential solid-state micropore approach is reported that detects a very low number of tumor cells from blood samples. One micropore is functionalized with an aptamer molecule specific to epidermal growth factor receptor (EGFR), known to be overexpressed on cancer cell surfaces, whereas the other micropore is bare. The translocation behavior of tumor cells is seen to be distinctly different from normal counterparts and control when passed through functionalized micropore. The differentiation stems from the selective interactions between the aptamer molecules and overexpressed EGFR on the tumor cells. Normal cells, on the other hand, do not show selective interaction with aptamers. As a result, cancer cells are distinguished from normal cells just by looking at the translocation data from an aptamer-functionalized micropore. The interactions between the cells and the aptamer in a micropore provide a detection modality that interrogates each cell.
Starting Page	983
Ending Page	992
Page Count	10
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	17
Issue Number	6
e-ISSN	16134990
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-06-03
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Aptamer Cancer Cell EGFR Functionalization Micropore Cell translocation behavior Engineering Fluid Dynamics Biomedical Engineering Analytical Chemistry Nanotechnology and Microengineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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