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| Content Provider | Springer Nature Link |
|---|---|
| Author | Cui, Shuo He, Zhong zhou Zhu, Zi wei Sun, Zhao Xu, Yi tong Wang, Jia liang Bao, Yan ying Ji, De yu Liu, Shun Liu, Jing tai Zhang, Jin hui Wang, Qi |
| Copyright Year | 2014 |
| Abstract | Polluting particulate matter suspended in the air is a leading cause of lung carcinogenesis, a process often accompanied by epithelial to mesenchymal transition (EMT) of the bronchial epithelium. By providing a continuous supply of nutrients, microfluidic chips simulate the spatial characteristics of the cellular environment to enable integrated, flexible and high-throughput analysis of cell growth and function. Here, we used a microfluidic chip to evaluate the effects of the air pollutant PM2.5 on EMT in human bronchial epithelial 16HBE cells and on alveolar macrophage chemotaxis. PM2.5 induced NF-κB, PI3K, Snail and N-cadherin levels and repressed E-cadherin levels in 16HBE cells and promoted macrophage chemotaxis. Collectively, our results indicate that PM2.5 causes EMT in bronchial epithelial cells via induction of inflammatory pathways and shed light upon its pathological effects in humans. |
| Starting Page | 263 |
| Ending Page | 272 |
| Page Count | 10 |
| File Format | |
| ISSN | 16134982 |
| Journal | Microfluidics and Nanofluidics |
| Volume Number | 19 |
| Issue Number | 2 |
| e-ISSN | 16134990 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2014-10-08 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | PM2.5 EMT Microfluidic chip TGF-β NF-κB PI3K Snail Cadherin Engineering Fluid Dynamics Biomedical Engineering Analytical Chemistry Nanotechnology and Microengineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials |
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