NDLI: On-demand, parallel droplet merging method with non-contact droplet pairing in droplet-based microfluidics

Content Provider	Springer Nature Link
Author	Lee, Sanghyun Kim, Hojin Won, Dong Joon Lee, Jaehyung Kim, Joonwon
Copyright Year	2015
Abstract	We demonstrate a simple approach for merging droplets in an on-demand, parallel manner via non-contact pairing of two droplets. The non-contact pairing can be achieved by exploiting flow-induced deformability of a droplet with a unique structure of merging element. Non-contact paired droplets, which are initially stabilized by surfactant molecules, can be merged simply by destabilizing the droplet interface and bringing two droplets into contact. On-demand, parallel droplet merging is performed with a proper pressure profile achieved by a pneumatic pressure supply system, and merging process is solely dependent on the pressure-driven fluid flow. We achieved an average merging efficiency of 90.0 % (SD = 3.14, n = 450) in performing parallel merging in a non-contact paired droplet array. We also evaluated the on-demand merging performance by measuring the average merging delay time (mean = 3.25 s, SD ± 1.09 s, n ~ 180). Furthermore, we demonstrated the applicability of our device for the initiation of a chemical reaction through the merging of two droplets with different chemical contents. We believe that the proposed method will be useful for studying various droplet-based reactions.
Starting Page	1
Ending Page	9
Page Count	9
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	20
Issue Number	1
e-ISSN	16134990
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-01-05
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Droplet-based microfluidics Deformability On-demand droplet merging Laplace trap Non-contact pairing Engineering Fluid Dynamics Biomedical Engineering Analytical Chemistry Nanotechnology and Microengineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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