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| Content Provider | Springer Nature Link |
|---|---|
| Author | Mishra, Anuja Starly, Binil |
| Copyright Year | 2009 |
| Abstract | Quantitative non-invasive measurement of critical physiological parameters is necessary to assess the functionality and applicability of tissue engineered matrices. Advancements in fiber optic sensors have made it possible for measuring parameters such as oxygen, glucose, and aminoacids necessary for viable tissue growth. In this study, we have devised an experimental protocol to measure in real time, the oxygen uptake rate (OUR) values for a selected liver cell line (HEPG2) when grown (a) on cover glass slides, and (b) encapsulated within alginate based hydrogel matrices. For both cases, the oxygen uptake rates of HEPG2 cells at selected time points varied in close co-relation with cell proliferation and metabolic activity during the 7-day culture period. This investigation concludes that OUR can be used as an indicative parameter to assess the metabolic activity of cells encapsulated within a matrix. The study also presents a fiber optic sensing technology as a non-invasive diagnostic tool to monitor cell behavior and activity. |
| Starting Page | 373 |
| Ending Page | 381 |
| Page Count | 9 |
| File Format | |
| ISSN | 16134982 |
| Journal | Microfluidics and Nanofluidics |
| Volume Number | 6 |
| Issue Number | 3 |
| e-ISSN | 16134990 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2009-01-23 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Oxygen uptake rate (OUR) Fiber optic sensor Alginate HEPG2 liver cells Biomedical Engineering Engineering Fluid Dynamics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials |
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