NDLI: Microfluidic-based biosensors toward point-of-care detection of nucleic acids and proteins

Content Provider	Springer Nature Link
Author	Choi, Seokheun Goryll, Michael Sin, Lai Yi Mandy Wong, Pak Kin Chae, Junseok
Copyright Year	2010
Abstract	This article reviews state-of-the-art microfluidic biosensors of nucleic acids and proteins for point-of-care (POC) diagnostics. Microfluidics is capable of analyzing small sample volumes (10−9–10−18 l) and minimizing costly reagent consumption as well as automating sample preparation and reducing processing time. The merger of microfluidics and advanced biosensor technologies offers new promises for POC diagnostics, including high-throughput analysis, portability and disposability. However, this merger also imposes technological challenges on biosensors, such as high sensitivity and selectivity requirements with sample volumes orders of magnitude smaller than those of conventional practices, false response errors due to non-specific adsorption, and integrability with other necessary modules. There have been many prior review articles on microfluidic-based biosensors, and this review focuses on the recent progress in last 5 years. Herein, we review general technologies of DNA and protein biosensors. Then, recent advances on the coupling of the biosensors to microfluidics are highlighted. Finally, we discuss the key challenges and potential solutions for transforming microfluidic biosensors into POC diagnostic applications.
Starting Page	231
Ending Page	247
Page Count	17
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	10
Issue Number	2
e-ISSN	16134990
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-06-02
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Microfluidics Biosensor Point-of-care detection Protein DNA Biomedical Engineering Industrial Chemistry/Chemical Engineering Engineering Fluid Dynamics
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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