NDLI: Analysis of mixed motion in deterministic ratchets via experiment and particle simulation

Content Provider	Springer Nature Link
Author	Kulrattanarak, T. Sman, R. G. M. Schroën, C. G. P. H. Boom, R. M.
Copyright Year	2010
Abstract	Deterministic lateral displacement (DLD) ratchets are microfluidic devices, which are used for size-based sorting of cells or DNA. Based on their size, particles are showing different kinds of motion, leading to their fractionation. In earlier studies, so-called zigzag and displacement motions are observed, and in recent study by our group (Kulrattanarak et al., Meas Sci Technol, 2010a; J Colloid Interface Sci, 2010b), we have shown that also mixed motion occurs, which is an irregular alternation of zigzag and displacement motion. We have shown that the mixed motion is due to asymmetry of the flow lane distribution, induced by the symmetry breaking of the oblique primitive lattice cell (Kulrattanarak et al. 2010b). In this study, we investigate mixed motion in depth by numerical and experimental analysis. Via 3D simulations, we have computed explicit particle trajectories in DLD, and are able to show that there are two critical length scales determining the type of motion. The first length scale d f,1 is the first flow lane width, which determines the transition between zigzag motion and mixed motion. The other length scale, d f,c, determines the transition between mixed motion and displacement motion. Based on our experimental and numerical results we have been able to correlate the migration angle of particles showing mixed motion to the particle size, relative to the two critical length scales d f,1 and d f,c.
Starting Page	843
Ending Page	853
Page Count	11
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	10
Issue Number	4
e-ISSN	16134990
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-10-24
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Deterministic ratchet Fractionation Numerical simulation Mixed motion Engineering Fluid Dynamics Biomedical Engineering Industrial Chemistry/Chemical Engineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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