NDLI: Analysis of chaos and FRET reaction in split-and-recombine microreactors

Content Provider	Springer Nature Link
Author	Chen, Yu Tzu Fang, Wei Feng Liu, Yen Cheng Yang, Jing Tang
Copyright Year	2011
Abstract	The mixing and reaction performance of a split-and-recombine (SAR) microreactor was enhanced on modification of the geometric configuration. A rotation of fluid is induced on shrinking the structure of the splitting and reorientation region in alternate directions, thus improving the pattern of multi-lamination and enhancing the chaos of the fluid. To design and to analyze systematically the performance of the reactors, an effective method involving chaotic analysis and fluorescent resonant-energy transfer (FRET) is proposed. The structural design of a passive microreactor to generate an effective contact between the reagents is of great practical significance. SAR microreactors of four types with various microstructures were designed to illustrate the effects of geometric patterns (i.e., arrangement and dimensions) on mixing and reaction. Through analysis of the chaos, we revealed numerically the dynamic mixing governed by multi-lamination and chaotic mechanisms in the devices. The results show that specific structural designs induce rotation and rearrangement of fluids, thus elongating their material interface; the mixing of the fluids consequently improved. We investigated the hybridization of two complementarily labeled oligonucleotides in the devices by means of FRET. How the devices affected the rate of hybridization was thereby assessed, verifying that FRET is a technique capable of estimating the practical applicability of these devices.
Starting Page	339
Ending Page	352
Page Count	14
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	11
Issue Number	3
e-ISSN	16134990
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-04-17
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Chaotic Split-and-recombine Mixing FRET Microreactor Biomedical Engineering Engineering Fluid Dynamics Industrial Chemistry/Chemical Engineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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