NDLI: Comparison of the Separation Characteristics of the Organic–Inorganic Hybrid Octadecyl Stationary Phases XTerra MS C18 and XBridge C18 and Shield RP18 in RPLC

Content Provider	Springer Nature Link
Author	Kiridena, Waruna Poole, Colin F. Atapattu, Sanka N. Qian, Jing Koziol, Wladyslaw W.
Copyright Year	2007
Abstract	Differences in the system constants of the solvation parameter model, discontinuities in retention factor plots (log k against volume fraction of organic solvent) and retention factor correlation plots are used to study the retention mechanism on XTerra MS C18, XBridge C18 and XBridge Shield RP18 stationary phases with acetonitrile–water and methanol–water mobile phases containing from 10 to 70% (v/v) organic solvent. Wetting of XBridge C18 at 10 and 20% (v/v) acetonitrile is incomplete and is responsible for small changes in the retention mechanism. The intermolecular interactions responsible for retention on XTerra MS C18 and XBridge C18 are similar with minor differences in cavity formation and hydrogen-bonding interactions responsible for small selectivity differences. On the other hand, for bulky solutes there are large changes in retention at low volume fractions of organic solvent (<40% v/v) associated with steric repulsion on the XTerra MS C18 stationary phases that is absent for XBridge C18. Selectivity differences are more apparent for XBridge C18 and XBridge Shield RP18. For acetonitrile-water mobile phases cavity formation in the solvated XBridge Shield RP18 is slightly more difficult and hydrogen-bond acid and base interactions are more important than for XBridge C18. With methanol–water mobile phases it becomes slightly easier to form a cavity in the solvated XBridge RP18 compared with XBridge C18. In addition, the methanol-water solvated XBridge RP18 is a stronger hydrogen-bond base and more dipolar/polarizable than XBridge C18. These variations in selectivity justify the use of XBridge C18 and XBridge Shield RP18 as complementary stationary phases for method development.
Starting Page	453
Ending Page	460
Page Count	8
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	66
Issue Number	7-8
e-ISSN	16121112
Language	English
Publisher	Vieweg Verlag
Publisher Date	2007-08-09
Publisher Place	Wiesbaden
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Column liquid chromatography Solvation parameter model Organic–inorganic hybrid Retention mechanism Stationary phase Measurement Science, Instrumentation Plant Sciences Biochemistry Pharmacy Organic Chemistry Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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