NDLI: LC Determination and Pharmacokinetics Study of Mangiferin in Rat Plasma and Tissues

Content Provider	Springer Nature Link
Author	Li, Yu Juan Sui, Ying Jie Dai, Yue Han Deng, Yu Lin
Copyright Year	2008
Abstract	An LC method was developed for determination of mangiferin in rat plasma and tissues after oral administration of Rhizoma Anemarrhenae extract. Analysis was performed on a Gemini C18 analytical column (250 × 4.6 mm, i.d.) with mobile phase consisting of acetonitrile–water (23:77, v/v) with 1% acetic acid and 1% tetrahydrofuran at a flow rate of 0.7 mL min−1. Spinosin was used as internal standard and UV detector was set at 320 nm. The calibration curve of mangiferin in rat plasma and tissues showed excellent linear behaviors over the investigated concentration ranges with the value of R 2 higher than 0.994. The within-day and between-day precisions for all samples were measured to be below 11.0%. The limit of quantitation was low enough for determination of mangiferin in all samples. After Rhizoma Anemarrhenae extract was orally administered to rats, the main pharmacokinetic parameters of mangiferin T max, C max, T 0.5α , T 0.5β , AUC0 − T and Vc were 4.20 h, 9.52 μg mL−1, 1.21 h, 1.71 h, 29.9 mg h L−1 and 0.18 L kg−1, respectively. Mangiferin was extensively distributed in most of the main tissues of rats. This validated method has been successfully applied to preliminary pharmacokinetics and tissue distribution study of mangiferin in rats.
Starting Page	957
Ending Page	960
Page Count	4
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	67
Issue Number	11-12
e-ISSN	16121112
Language	English
Publisher	Vieweg Verlag
Publisher Date	2008-04-18
Publisher Place	Wiesbaden
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Column liquid chromatography Pharmacokinetic study Rhizoma Anemarrhenae extract Magiferin Measurement Science, Instrumentation Plant Sciences Biochemistry Pharmacy Organic Chemistry Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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