NDLI: Preparation and Evaluation of Long Chain Alkyl Methacrylate Monoliths for Capillary Chromatography

Content Provider	Springer Nature Link
Author	ALOthman, Zeid A. Aqel, Ahmad Al Abdelmoneim, Hadeel A. Yacine Badjah Hadj Ahmed, A. Al Warthan, Abdulrahman A.
Copyright Year	2011
Abstract	This work describes the fabrication of long chain alkyl methacrylate monolithic materials for use as stationary phases in capillary liquid chromatography. After capillary inner wall surface activation with 3-(trimethoxysilyl)propyl methacrylate, monoliths were formed by copolymerization of either lauryl or stearyl methacrylate (LMA or SMA) with ethylene dimethacrylate (EDMA) as crosslinker, in the presence of azobisisobutyronitrile (AIBN) as initiator and a mixture of porogenic solvents including water, 1-propanol and 1,4-butanediol. The composition of the polymerization mixture was changed in terms of monomer, crosslinker and porogen ratio composition, in order to compare the influence of these parameters. The monoliths were prepared in 320 μm i.d. and 200 mm length capillaries. The column morphology was characterized by optical microscopy and scanning electron microscopy (SEM). Total porosity and permeability of each column were calculated using uracil as unretained material by measuring the pressure drop across the columns as a function of linear velocity. The microglobule average size for each column was also determined using Hagen–Poiseuille equation and compared with the SEM images. As expected, a decrease of the porogen to monomer ratio corresponded to smaller microglobules and a lower total porosity. The columns were then chromatographically evaluated; good results were obtained when these capillaries were used to separate mixtures of phenols, aromatics and drug compounds.
Starting Page	1
Ending Page	8
Page Count	8
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	74
Issue Number	1-2
e-ISSN	16121112
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-05-15
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Capillary liquid chromatography Monolithic column Lauryl methacrylate Stearyl methacrylate Ethylene dimethacrylate Biochemistry Organic Chemistry Analytical Chemistry Plant Sciences Proteomics Pharmacy
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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