NDLI: Low-Pressure Chromatographic Separation of p-Hydroxybenzoates Using Sequential Injection with Lab-on-Valve System and Miniature Monolithic Column

Content Provider	Springer Nature Link
Author	Kradtap Hartwell, Supaporn Kehling, Alison Lapanantppakhun, Somchai
Copyright Year	2014
Abstract	The use of a small guard column (5-mm length) as a miniature analytical column in low-pressure liquid chromatography based on a sequential injection with lab-on-valve system was demonstrated. A strong initial mobile phase was used to rapidly deliver the sample zone to the column prior to simultaneous separation of analytes with weaker mobile phase. Separation of methyl-, ethyl-, propyl-, and butyl-4-hydroxybenzoates (MP, EP, PP, and BP) was achieved within about 120 s with sufficient peak resolution (all higher than 1.3) using 2,500 µL of mobile phase (composed of 1,087 µL of MeOH) per run. Detection limits were found to be 6.5, 8.0, 0.5, and 0.6 μmol L−1 for MP, EP, PP, and BP, respectively. The system was tested with common commercially available skin lotions and wet wipe products. The analysis results were in good agreement with those obtained from the high-performance liquid chromatography with a 10-cm-length packed column.
Starting Page	883
Ending Page	891
Page Count	9
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	77
Issue Number	13-14
e-ISSN	16121112
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-05-29
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Sequential injection chromatography Low-pressure chromatography Lab-on-valve p-Hydroxybenzoates Parabens Chromatography Proteomics Pharmacy Laboratory Medicine
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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