NDLI: Enantioseparation of Chiral Epoxides with Polysaccharide-Based Chiral Columns in HPLC

Content Provider	Springer Nature Link
Author	Lomsadze, Ketevan Merlani, Maia Barbakadze, Vakhtang Farkas, Tivadar Chankvetadze, Bezhan
Copyright Year	2012
Abstract	Polysaccharide-based chiral columns were evaluated for the separation of enantiomers of four chiral epoxides under normal-phase and polar organic mode. Since all four studied compounds contain two centers of chirality and, thus, theoretically, the coexistence of four stereoisomers is possible, the columns were evaluated from the viewpoints of both, chemoselectivity and enantioselectivity. For two of the epoxides, enantioseparation was achieved in the normal-phase mode as well as in the polar organic mode on several polysaccharide columns. The polar organic mode is especially attractive for the preparative separation of the enantiomers due to the enhanced solubility of the compounds in these solvents, as well as due to a shorter run time. A new and unusual (stereoselective) peak focusing phenomenon was observed in some experiments.
Starting Page	839
Ending Page	845
Page Count	7
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	75
Issue Number	15-16
e-ISSN	16121112
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-07-17
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Chiral epoxides Column liquid chromatography Separation of enantiomers Polysaccharide-based chiral columns Chromatography Pharmacy Proteomics Laboratory Medicine
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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