NDLI: Biotransformation of benzonitrile herbicides via the nitrile hydratase

Content Provider	Springer Nature Link
Author	Veselá, Alicja B. Pelantová, Helena Šulc, Miroslav Macková, Martina Lovecká, Petra Thimová, Markéta Pasquarelli, Fabrizia Pičmavá, Martina Pátek, Miroslav Bhalla, Tek Chand Martínková, Ludmila
Copyright Year	2012
Abstract	The aim of this work was to determine the ability of rhodococci to transform 3,5-dichloro-4-hydroxybenzonitrile (chloroxynil), 3,5-dibromo-4-hydroxybenzonitrile (bromoxynil), 3,5-diiodo-4-hydroxybenzonitrile (ioxynil) and 2,6-dichlorobenzonitrile (dichlobenil); to identify the products and determine their acute toxicities. Rhodococcus erythropolis A4 and Rhodococcus rhodochrous PA-34 converted benzonitrile herbicides into amides, but only the former strain was able to hydrolyze 2,6-dichlorobenzamide into 2,6-dichlorobenzoic acid, and produced also more of the carboxylic acids from the other herbicides compared to strain PA-34. Transformation of nitriles into amides decreased acute toxicities for chloroxynil and dichlobenil, but increased them for bromoxynil and ioxynil. The amides inhibited root growth in Lactuca sativa less than the nitriles but more than the acids. The conversion of the nitrile group may be the first step in the mineralization of benzonitrile herbicides but cannot be itself considered to be a detoxification.
Starting Page	1811
Ending Page	1819
Page Count	9
File Format	PDF
ISSN	13675435
Journal	Journal of Industrial Microbiology and Biotechnology
Volume Number	39
Issue Number	12
e-ISSN	14765535
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-08-26
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	Nitrile hydratase Amidase Benzonitrile herbicides Rhodococcus erythropolis Rhodococcus rhodochrous Inorganic Chemistry Biotechnology Genetic Engineering Biochemistry Bioinformatics Microbiology
Content Type	Text
Resource Type	Article
Subject	Medicine Bioengineering Applied Microbiology and Biotechnology Biotechnology

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Biotransformation of nitriles to amides using soluble and immobilized nitrile hydratase from Rhodococcus erythropolis A4

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