NDLI: Killing bacterial spores by organic hydroperoxides

Content Provider	Springer Nature Link
Author	Setlow, C A
Copyright Year	1997
Abstract	Killing of wild-type spores of Bacillus subtilis by t-butyl hydroperoxide, cumene hydroperoxide and peracetic acid was not through DNA damage, as shown by the absence of mutations in the survivors and the identical sensitivity of spores of strains with or without a recA mutation. In contrast, B. subtilis spores (termed α−β−) lacking the DNA protective α/β-type small, acid-soluble spore proteins (SASP) were more sensitive to t-butyl hydroperoxide and cumene hydroperoxide, and their killing was in large part through DNA damage, as shown by the high frequency of mutations in the survivors and the greater sensitivity of α−β− recA spores. Analysis of t-butyl hydroperoxide-treated spores showed that generation of DNA damage in α−β− spores was more rapid than in wild-type spores; α/β-type SASP also protected against DNA strand breakage in vitro caused by t-butyl hydroperoxide. α/β-Type SASP appeared to play no role in protection of spores from killing by peracetic acid; wild-type and α−β− spores exhibited identical peracetic acid sensitivity and their killing by this agent appeared to be not through DNA damage.
Starting Page	384
Ending Page	388
Page Count	5
File Format	PDF
ISSN	13675435
Journal	Journal of Industrial Microbiology and Biotechnology
Volume Number	18
Issue Number	6
e-ISSN	14765535
Language	English
Publisher	Nature Publishing Group
Publisher Date	1997-06-01
Publisher Place	London
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article
Subject	Medicine Bioengineering Applied Microbiology and Biotechnology Biotechnology

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