NDLI: Mucosal vaccine delivery by non-recombinant spores of Bacillus subtilis

Please wait, while we are loading the content...

Year: 2016, Volume: 15

Year: 2015, Volume: 14

Year: 2014, Volume: 13

Year: 2014, Volume: 13, Issue: Unspecified

The Aspergillus nidulans Zn(II)2Cys6 transcription factor AN5673/RhaR mediates L-rhamnose utilization and the production of α-L-rhamnosidases

Microbial production of short chain diols

Improving itaconic acid production through genetic engineering of an industrial Aspergillus terreus strain

Transcription analysis of recombinant industrial and laboratory Saccharomyces cerevisiae strains reveals the molecular basis for fermentation of glucose and xylose

Engineering Escherichia coli K12 MG1655 to use starch

Dissecting and engineering of the TetR family regulator SACE_7301 for enhanced erythromycin production in Saccharopolyspora erythraea

Assessment of metabolic flux distribution in the thermophilic hydrogen producer Caloramator celer as affected by external pH and hydrogen partial pressure

Effect of elevated oxygen concentration on bacteria, yeasts, and cells propagated for production of biological compounds

Annual acknowledgement of manuscript reviewers

Increased 3-hydroxypropionic acid production from glycerol, by modification of central metabolism in Escherichia coli

Genetically shaping morphology of the filamentous fungus Aspergillus glaucus for production of antitumor polyketide aspergiolide A

Production of the short peptide surfactant DAMP4 from glucose or sucrose in high cell density cultures of Escherichia coli BL21(DE3)

Getting lipids from glycerol: new perspectives on biotechnological exploitation of Candida freyschussii

The metabolic potential of Escherichia coli BL21 in defined and rich medium

Biosynthesis of β-carotene in engineered E. coli using the MEP and MVA pathways

Yeast biotechnology: teaching the old dog new tricks

Differential proteomic profiling reveals regulatory proteins and novel links between primary metabolism and spinosad production in Saccharopolyspora spinosa

Engineering Escherichia coli to overproduce aromatic amino acids and derived compounds

Genome-scale metabolic network reconstruction of Saccharopolyspora spinosa for Spinosad Production improvement

Fermentation-induced variation in heat and oxidative stress phenotypes of Lactococcus lactis MG1363 reveals transcriptome signatures for robustness

Bacterial degradation of chlorophenols and their derivatives

Production of recombinant protein by a novel oxygen-induced system in Escherichia coli

Deletion of the gene encoding the reductase component of 3-ketosteroid 9α-hydroxylase in Rhodococcus equi USA-18 disrupts sterol catabolism, leading to the accumulation of 3-oxo-23,24-bisnorchola-1,4-dien-22-oic acid and 1,4-androstadiene-3,17-dione

Insights into glycogen metabolism in Lactobacillus acidophilus: impact on carbohydrate metabolism, stress tolerance and gut retention

Metabolomic basis of laboratory evolution of butanol tolerance in photosynthetic Synechocystis sp. PCC 6803

Stepwise metabolic adaption from pure metabolization to balanced anaerobic growth on xylose explored for recombinant Saccharomyces cerevisiae

Characterization of an Ebosin derivative produced by heterologous gene replacement in Streptomyces sp. 139

Influence of substrate on electricity generation of Shewanella loihica PV-4 in microbial fuel cells

Modified ‘one amino acid-one codon’ engineering of high GC content TaqII-coding gene from thermophilic Thermus aquaticus results in radical expression increase

Using ionic liquids in whole-cell biocatalysis for the nucleoside acylation

Novel nikkomycin analogues generated by mutasynthesis in Streptomyces ansochromogenes

Genetic and biochemical approaches towards unravelling the degradation of gallotannins by Streptococcus gallolyticus

The use of fosmid metagenomic libraries in preliminary screening for various biological activities

Highly efficient L-lactate production using engineered Escherichia coli with dissimilar temperature optima for L-lactate formation and cell growth

Efficient ammonium uptake and mobilization of vacuolar arginine by Saccharomyces cerevisiae wine strains during wine fermentation

Fourier transform infrared spectroscopy for the prediction of fatty acid profiles in Mucor fungi grown in media with different carbon sources

Phenotypic characterisation of Saccharomyces spp. yeast for tolerance to stresses encountered during fermentation of lignocellulosic residues to produce bioethanol

Microbial production of sabinene—a new terpene-based precursor of advanced biofuel

Enhancement of acetoin production in Candida glabrata by in silico-aided metabolic engineering

Design and implementation of a high yield production system for recombinant expression of peptides

Antisense knockdown of pyruvate dehydrogenase kinase promotes the neutral lipid accumulation in the diatom Phaeodactylum tricornutum

Decrease of UPR- and ERAD-related proteins in Pichia pastoris during methanol-induced secretory insulin precursor production in controlled fed-batch cultures

Delivery of a functional anti-trypanosome Nanobody in different tsetse fly tissues via a bacterial symbiont, Sodalis glossinidius

Autodisplay for the co-expression of lipase and foldase on the surface of E. coli: washing with designer bugs

Biomass and RRR-α-tocopherol production in Stichococcus bacillaris strain siva2011 in a balloon bioreactor

Se (IV) triggers faster Te (IV) reduction by soil isolates of heterotrophic aerobic bacteria: formation of extracellular SeTe nanospheres

Succinic acid production with Actinobacillus succinogenes: rate and yield analysis of chemostat and biofilm cultures

An Air-well sparging minifermenter system for high-throughput protein production

Optimization of the recombinant production and purification of a self-assembling peptide in Escherichia coli

Cyanobacterial biofuels: new insights and strain design strategies revealed by computational modeling

Calcium-containing phosphopeptides pave the secretory pathway for efficient protein traffic and secretion in fungi

The role of protein modifications in senescence of freeze-dried Acetobacter senegalensis during storage

Metabolic engineering of Escherichia coli for the production of riboflavin

Secreted production of assembled Norovirus virus-like particles from Pichia pastoris

Inorganic phosphate is a trigger factor for Microbispora sp. ATCC-PTA-5024 growth and NAI-107 production

Use of chemostat cultures mimicking different phases of wine fermentations as a tool for quantitative physiological analysis

Improved productivity of poly (4-hydroxybutyrate) (P4HB) in recombinant Escherichia coli using glycerol as the growth substrate with fed-batch culture

Conversion of cellulosic materials into glycolipid biosurfactants, mannosylerythritol lipids, by Pseudozyma spp. under SHF and SSF processes

Double mutation of cell wall proteins CspB and PBP1a increases secretion of the antibody Fab fragment from Corynebacterium glutamicum

Process inhomogeneity leads to rapid side product turnover in cultivation of Corynebacterium glutamicum

Effect of metal catalyzed oxidation in recombinant viral protein assemblies

Steroid conversion with CYP106A2 – production of pharmaceutically interesting DHEA metabolites

The artificial neural network approach based on uniform design to optimize the fed-batch fermentation condition: application to the production of iturin A

Genome-scale metabolic network reconstruction and in silico flux analysis of the thermophilic bacterium Thermus thermophilus HB27

The naturally competent strain Streptococcus thermophilus LMD-9 as a new tool to anchor heterologous proteins on the cell surface

Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process

Metabolic engineering of Pseudomonas sp. strain VLB120 as platform biocatalyst for the production of isobutyric acid and other secondary metabolites

Metabolic engineering and classical selection of the methylotrophic thermotolerant yeast Hansenula polymorpha for improvement of high-temperature xylose alcoholic fermentation

Aspergillus oryzae-based cell factory for direct kojic acid production from cellulose

Generation of human ER chaperone BiP in yeast Saccharomyces cerevisiae

A variant of green fluorescent protein exclusively deposited to active intracellular inclusion bodies

Isolation, characterization and application of a cellulose-degrading strain Neurospora crassa S1 from oil palm empty fruit bunch

Pitfalls in optical on-line monitoring for high-throughput screening of microbial systems

Effects of MIG1, TUP1 and SSN6 deletion on maltose metabolism and leavening ability of baker’s yeast in lean dough

Artificial symbiosis for acetone-butanol-ethanol (ABE) fermentation from alkali extracted deshelled corn cobs by co-culture of Clostridium beijerinckii and Clostridium cellulovorans

Antibiotic-free segregational plasmid stabilization in Escherichia coli owing to the knockout of triosephosphate isomerase (tpiA)

Catechol biosynthesis from glucose in Escherichia coli anthranilate-overproducer strains by heterologous expression of anthranilate 1,2-dioxygenase from Pseudomonas aeruginosa PAO1

Substrate dependent in vitro antifungal activity of Bacillus sp strain AR2

A new fusion protein platform for quantitatively measuring activity of multiple proteases

Deleting multiple lytic genes enhances biomass yield and production of recombinant proteins by Bacillus subtilis

Biotransformation and chemotaxis of 4-chloro-2-nitrophenol by Pseudomonas sp. JHN

Suitable extracellular oxidoreduction potential inhibit rex regulation and effect central carbon and energy metabolism in Saccharopolyspora spinosa

Development of a two-step cultivation strategy for the production of vitamin B12 by Bacillus megaterium

MEP pathway-mediated isopentenol production in metabolically engineered Escherichia coli

An engineered autotransporter-based surface expression vector enables efficient display of Affibody molecules on OmpT-negative E. coli as well as protease-mediated secretion in OmpT-positive strains

MB109 as bioactive human bone morphogenetic protein-9 refolded and purified from E. coli inclusion bodies

Delayed formation of zero-valent selenium nanoparticles by Bacillus mycoides SeITE01 as a consequence of selenite reduction under aerobic conditions

Improved production of fatty acid ethyl esters in Saccharomyces cerevisiae through up-regulation of the ethanol degradation pathway and expression of the heterologous phosphoketolase pathway

Global transcriptomic analysis of an engineered Escherichia coli strain lacking the phosphoenolpyruvate: carbohydrate phosphotransferase system during shikimic acid production in rich culture medium

Deregulation of purine pathway in Bacillus subtilis and its use in riboflavin biosynthesis

Furaldehyde substrate specificity and kinetics of Saccharomyces cerevisiae alcohol dehydrogenase 1 variants

A comparative study: the impact of different lipid extraction methods on current microalgal lipid research

The important ergot alkaloid intermediate chanoclavine-I produced in the yeast Saccharomyces cerevisiae by the combined action of EasC and EasE from Aspergillus japonicus

A high-throughput, restriction-free cloning and screening strategy based on ccdB-gene replacement

Impact of tobramycin on the performance of microbial fuel cell

Tuning constitutive recombinant gene expression in Lactobacillus plantarum

Quality assessment and optimization of purified protein samples: why and how?

Current development in genetic engineering strategies of Bacillus species

Mucosal vaccine delivery by non-recombinant spores of Bacillus subtilis

A reduced genome decreases the host carrying capacity for foreign DNA

Direct production of itaconic acid from liquefied corn starch by genetically engineered Aspergillus terreus

Flux analysis of the Lactobacillus reuteri propanediol-utilization pathway for production of 3-hydroxypropionaldehyde, 3-hydroxypropionic acid and 1,3-propanediol from glycerol

A bacteriocin gene cluster able to enhance plasmid maintenance in Lactococcus lactis

Effects of aromatic compounds on the production of bacterial nanocellulose byGluconacetobacter xylinus

Production of medium chain length polyhydroxyalkanoate in metabolic flux optimized Pseudomonas putida

An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines

High-temperature cultivation of recombinant Pichia pastoris increases endoplasmic reticulum stress and decreases production of human interleukin-10

Use of Ubp1 protease analog to produce recombinant human growth hormone in Escherichia coli

Correction: Production of hydroxycinnamoyl anthranilates from glucose in Escherichia coli

Changes in SAM2 expression affect lactic acid tolerance and lactic acid production in Saccharomyces cerevisiae

Elucidation of intrinsic biosynthesis yields using 13C-based metabolism analysis

Biomass pyrolysis liquid to citric acid via 2-step bioconversion

Expanding the recombinant protein quality in Lactococcus lactis

High-quality production of human α-2,6-sialyltransferase in Pichia pastoris requires control over N-terminal truncations by host-inherent protease activities

Metabolic flux responses to genetic modification for shikimic acid production by Bacillus subtilis strains

Effect of oxygenation and temperature on glucose-xylose fermentation in Kluyveromyces marxianus CBS712 strain

Influence of pH control in the formation of inclusion bodies during production of recombinant sphingomyelinase-D in Escherichia coli

L-lactic acid production from D-xylose with Candida sonorensis expressing a heterologous lactate dehydrogenase encoding gene

Highly purified mussel adhesive protein to secure biosafety for in vivo applications

Expression of the Aspergillus terreus itaconic acid biosynthesis cluster in Aspergillus niger

Development of a genetic system for the deep-sea psychrophilic bacterium Pseudoalteromonas sp. SM9913

Improvement of L-phenylalanine production from glycerol by recombinant Escherichia coli strains: The role of extra copies of glpK, glpX, and tktA genes

Recombinant S. cerevisiae expressing Old Yellow Enzymes from non-conventional yeasts: an easy system for selective reduction of activated alkenes

Use of non-growing Lactococcus lactis cell suspensions for production of volatile metabolites with direct relevance for flavour formation during dairy fermentations

Bacillus thuringiensis subsp. kurstaki HD1 as a factory to synthesize alkali-labile ChiA74∆sp chitinase inclusions, Cry crystals and spores for applied use

Development of a GIN11/FRT-based multiple-gene integration technique affording inhibitor-tolerant, hemicellulolytic, xylose-utilizing abilities to industrial Saccharomyces cerevisiae strains for ethanol production from undetoxified lignocellulosic hemicelluloses

Engineering of Serine-Deamination pathway, Entner-Doudoroff pathway and pyruvate dehydrogenase complex to improve poly(3-hydroxybutyrate) production in Escherichia coli

Smart sustainable bottle (SSB) system for E. coli based recombinant protein production

A system of vectors for Bacillus subtilis spore surface display

Use of titanium dioxide nanoparticles biosynthesized by Bacillus mycoides in quantum dot sensitized solar cells

Antiadhesive activity of poly-hydroxy butyrate biopolymer from a marine Brevibacterium casei MSI04 against shrimp pathogenic vibrios

Engineered baker’s yeast as whole-cell biocatalyst for one-pot stereo-selective conversion of amines to alcohols

Efficient production of single-chain fragment variable-based N-terminal trimerbodies in Pichia pastoris

Expression of single-chain variable fragments fused with the Fc-region of rabbit IgG in Leishmania tarentolae

De novo production of the monoterpenoid geranicacid by metabolically engineered Pseudomonas putida

Production of shikimic acid from Escherichia coli through chemically inducible chromosomal evolution and cofactor metabolic engineering

Comprehensive clone screening and evaluation of fed-batch strategies in a microbioreactor and lab scale stirred tank bioreactor system: application on Pichia pastoris producing Rhizopus oryzae lipase

Fermentation of oxidized hexose derivatives by Clostridium acetobutylicum

1,3-propanediol production with Citrobacter werkmanii DSM17579: effect of a dhaD knock-out

Phenotyping the quality of complex medium components by simple online-monitored shake flask experiments

Metabolic pathway for degradation of 2-chloro-4-aminophenol by Arthrobacter sp. SPG

Constitutive homologous expression of phosphoglucomutase and transaldolase increases the metabolic flux of Fusarium oxysporum

Exploiting Issatchenkia orientalis SD108 for succinic acid production

Secretion of a foreign protein from budding yeasts is enhanced by cotranslational translocation and by suppression of vacuolar targeting

Complete sucrose hydrolysis by heat-killed recombinant Pichia pastoris cells entrapped in calcium alginate

Developing a new production host from a blueprint: Bacillus pumilus as an industrial enzyme producer

A marine sponge associated strain of Bacillus subtilis and other marine bacteria can produce anticholinesterase compounds

The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway

First co-expression of a lipase and its specific foldase obtained by metagenomics

Expression of endoglucanases in Pichia pastoris under control of the GAP promoter

Development of bio-based fine chemical production through synthetic bioengineering

Pseudomonas 2.0: genetic upgrading of P. putida KT2440 as an enhanced host for heterologous gene expression

Carbon source dependent promoters in yeasts

Biotechnological production of carotenoids by yeasts: an overview

OpenFLUX2: 13C-MFA modeling software package adjusted for the comprehensive analysis of single and parallel labeling experiments

Enhanced production of L-sorbose from D-sorbitol by improving the mRNA abundance of sorbitol dehydrogenase in Gluconobacter oxydans WSH-003

Identification and characterization of the nitrate assimilation genes in the isolate of Streptomyces griseorubens JSD-1

Effects of abiotic stressors on lutein production in the green microalga Dunaliella salina

Rational selection and engineering of exogenous principal sigma factor (σHrdB) to increase teicoplanin production in an industrial strain of Actinoplanes teichomyceticus

Year: 2014, Volume: 13, Issue: Suppl 1

Year: 2013, Volume: 12

Year: 2012, Volume: 11

Year: 2011, Volume: 10

Year: 2010, Volume: 9

Year: 2009, Volume: 8

Year: 2008, Volume: 7

Year: 2007, Volume: 6

Year: 2006, Volume: 5

Year: 2005, Volume: 4

Year: 2004, Volume: 3

Year: 2003, Volume: 2

Year: 2002, Volume: 1

Mucosal vaccine delivery by non-recombinant spores of Bacillus subtilis

Content Provider	PubMed Central
Author	Ricca, Ezio Loredana, Baccigalupi Cangiano, Giuseppina Felice, Maurilio De Isticato, Rachele
Abstract	Development of mucosal vaccines strongly relies on an efficient delivery system and, over the years, a variety of approaches based on phages, bacteria or synthetic nanoparticles have been proposed to display and deliver antigens. The spore of Bacillus subtilis displaying heterologous antigens has also been considered as a mucosal vaccine vehicle, and shown able to conjugate some advantages of live microrganisms with some of synthetic nanoparticles. Here we review the use of non-recombinant spores of B. subtilis as a delivery system for mucosal immunizations. The non-recombinant display is based on the adsorption of heterologous molecules on the spore surface without the need of genetic manipulations, thus avoiding all concerns about the use and environmental release of genetically modified microorganisms. In addition, adsorbed molecules are stabilized and protected by the interaction with the spore, suggesting that this system could reduce the rapid degradation of the antigen, often observed with other delivery systems and identified as a major drawback of mucosal vaccines.
Related Links	http://dx.doi.org/10.1186/s12934-014-0115-2
Starting Page	115
File Format	PDF
ISSN	14752859
e-ISSN	14752859
Journal	Microbial Cell Factories
Volume Number	13
Language	English
Publisher	BioMed Central
Publisher Date	2014-12-01
Access Restriction	Open
Rights Holder	BioMed Central
Subject Keyword	Biotechnology Applied Microbiology and Biotechnology Bioengineering Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Bioengineering Applied Microbiology and Biotechnology Biotechnology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in