NDLI: Selective activity of Mucor plumbeus reductase towards (−)-camphorquinone

Content Provider	Springer Nature Link
Author	Souza, Giovanni Gontijo Anconi, Cleber Paulo Andrada Cornelissen, Sjef Almeida, Wagner Batista Dos Santos, Hélio Ferreira Fortes, Isabel Cristina Pereira Takahashi, Jacqueline Aparecida
Copyright Year	2009
Abstract	The biotransformation of 1R-(−)-camphorquinone, achieved by growing cells of four fungi species isolated from soil (Mucor plumbeus, Lecanicillium muscarium, Thamnostylum sp. and Syncephalastrum racemosum), was investigated in optimized culture media for each species. Fungi were grown aerobically under shaking and their activities with respect to camphorquinone were monitored for 20 days by gas chromatography coupled to mass spectrometry (GCMS). Camphorquinone was found to be stable in control flasks throughout the experiment. The most interesting results were found for M. plumbeus, which was only able to perform monoreduction of camphorquinone when cultivated on a glucose–peptone–yeast extract medium. Large-scale experiments were set up and the camphorquinone biotransformation products formed by M. plumbeus were purified by column chromatography and identified by 1H and 13C nuclear magnetic resonance (NMR). Theoretical calculations were employed as a complementary technique to unambiguously identify the biotransformation products. These findings suggest that M. plumbeus could be of great use for the selective reduction of camphorquinone and related compounds.
Starting Page	1023
Ending Page	1027
Page Count	5
File Format	PDF
ISSN	13675435
Journal	Journal of Industrial Microbiology and Biotechnology
Volume Number	36
Issue Number	8
e-ISSN	14765535
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-05-13
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	Camphorquinone Biotransformation Mucor plumbeus Stereoselectivity Microbiology Bioinformatics Biotechnology Genetic Engineering Inorganic Chemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Bioengineering Applied Microbiology and Biotechnology Biotechnology

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