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  1. Journal of Industrial Microbiology and Biotechnology
  2. Journal of Industrial Microbiology and Biotechnology : Volume 41
  3. Journal of Industrial Microbiology and Biotechnology : Volume 41, Issue 2, February 2014
  4. Activating secondary metabolism with stress and chemicals
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Journal of Industrial Microbiology and Biotechnology : Volume 44
Journal of Industrial Microbiology and Biotechnology : Volume 43
Journal of Industrial Microbiology and Biotechnology : Volume 42
Journal of Industrial Microbiology and Biotechnology : Volume 41
Journal of Industrial Microbiology and Biotechnology : Volume 41, Issue 12, December 2014
Journal of Industrial Microbiology and Biotechnology : Volume 41, Issue 11, November 2014
Journal of Industrial Microbiology and Biotechnology : Volume 41, Issue 10, October 2014
Journal of Industrial Microbiology and Biotechnology : Volume 41, Issue 9, September 2014
Journal of Industrial Microbiology and Biotechnology : Volume 41, Issue 8, August 2014
Journal of Industrial Microbiology and Biotechnology : Volume 41, Issue 7, July 2014
Journal of Industrial Microbiology and Biotechnology : Volume 41, Issue 6, June 2014
Journal of Industrial Microbiology and Biotechnology : Volume 41, Issue 5, May 2014
Journal of Industrial Microbiology and Biotechnology : Volume 41, Issue 4, April 2014
Journal of Industrial Microbiology and Biotechnology : Volume 41, Issue 3, March 2014
Journal of Industrial Microbiology and Biotechnology : Volume 41, Issue 2, February 2014
Sir David Alan Hopwood
Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?
Importance of microbial natural products and the need to revitalize their discovery
Challenges and triumphs to genomics-based natural product discovery
Evolutionary concepts in natural products discovery: what actinomycetes have taught us
Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways
Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters
Genome mining of Streptomyces ambofaciens
Identification of a vitamin D3-specific hydroxylase genes through actinomycetes genome mining
Genome-guided discovery of diverse natural products from Burkholderia sp.
Merging chemical ecology with bacterial genome mining for secondary metabolite discovery
Strategies for mining fungal natural products
Lessons learned from the transformation of natural product discovery to a genome-driven endeavor
Prospecting genomes for lasso peptides
Genomics-enabled discovery of phosphonate natural products and their biosynthetic pathways
MbtH homology codes to identify gifted microbes for genome mining
Triggers and cues that activate antibiotic production by actinomycetes
Actinomycetes biosynthetic potential: how to bridge in silico and in vivo?
Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements
Activating secondary metabolism with stress and chemicals
Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways
Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans
Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides
Strain-specific proteogenomics accelerates the discovery of natural products via their biosynthetic pathways
Predicting substrate specificity of adenylation domains of nonribosomal peptide synthetases and other protein properties by latent semantic indexing
DNA assembly techniques for next-generation combinatorial biosynthesis of natural products
Journal of Industrial Microbiology and Biotechnology : Volume 41, Issue 1, January 2014
Journal of Industrial Microbiology and Biotechnology : Volume 40
Journal of Industrial Microbiology and Biotechnology : Volume 39
Journal of Industrial Microbiology and Biotechnology : Volume 38
Journal of Industrial Microbiology and Biotechnology : Volume 37
Journal of Industrial Microbiology and Biotechnology : Volume 36
Journal of Industrial Microbiology and Biotechnology : Volume 35
Journal of Industrial Microbiology and Biotechnology : Volume 34
Journal of Industrial Microbiology and Biotechnology : Volume 33
Journal of Industrial Microbiology and Biotechnology : Volume 32
Journal of Industrial Microbiology and Biotechnology : Volume 31
Journal of Industrial Microbiology and Biotechnology : Volume 30
Journal of Industrial Microbiology and Biotechnology : Volume 29
Journal of Industrial Microbiology and Biotechnology : Volume 28
Journal of Industrial Microbiology and Biotechnology : Volume 27
Journal of Industrial Microbiology and Biotechnology : Volume 26
Journal of Industrial Microbiology and Biotechnology : Volume 25
Journal of Industrial Microbiology and Biotechnology : Volume 24
Journal of Industrial Microbiology and Biotechnology : Volume 23
Journal of Industrial Microbiology and Biotechnology : Volume 22
Journal of Industrial Microbiology and Biotechnology : Volume 21
Journal of Industrial Microbiology and Biotechnology : Volume 20
Journal of Industrial Microbiology and Biotechnology : Volume 19
Journal of Industrial Microbiology and Biotechnology : Volume 18

Activating secondary metabolism with stress and chemicals

Content Provider Springer Nature Link
Author Yoon, Vanessa dwell, Justin R.
Copyright Year 2013
Abstract The available literature on the secondary or nonessential metabolites of the streptomycetes bacteria suggests that there may be poorly expressed or “cryptic” compounds that have yet to be identified and that may have significant medical utility. In addition, it is clear that there is a large and complex regulatory network that controls the production of these molecules in the laboratory and in nature. Two approaches that have been taken to manipulating the yields of secondary metabolites are the use of various stress responses and, more recently, the use of precision chemical probes. Here, we review the status of this work and outline the challenges and opportunities afforded by each of them.
Starting Page 415
Ending Page 424
Page Count 10
File Format PDF
ISSN 13675435
Journal Journal of Industrial Microbiology and Biotechnology
Volume Number 41
Issue Number 2
e-ISSN 14765535
Language English
Publisher Springer Berlin Heidelberg
Publisher Date 2013-12-11
Publisher Place Berlin, Heidelberg
Access Restriction Subscribed
Subject Keyword Streptomyces metabolism Stress response Chemical probe Microbiology Biochemistry Inorganic Chemistry Genetic Engineering Biotechnology Bioinformatics
Content Type Text
Resource Type Article
Subject Medicine Bioengineering Applied Microbiology and Biotechnology Biotechnology
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