NDLI: Actinomycetes biosynthetic potential: how to bridge in silico and in vivo?

Content Provider	Springer Nature Link
Author	Rebets, Yuriy Brötz, Elke Tokovenko, Bogdan Luzhetskyy, Andriy
Copyright Year	2013
Abstract	Actinomycetes genome sequencing and bioinformatic analyses revealed a large number of “cryptic” gene clusters coding for secondary metabolism. These gene clusters have the potential to increase the chemical diversity of natural products. Indeed, reexamination of well-characterized actinomycetes strains revealed a variety of hidden treasures. Growing information about this metabolic diversity has promoted further development of strategies to discover novel biologically active compounds produced by actinomycetes. This new task for actinomycetes genetics requires the development and use of new approaches and tools. Application of synthetic biology approaches led to the development of a set of strategies and tools to satisfy these new requirements. In this review, we discuss strategies and methods to discover small molecules produced by these fascinating bacteria and also discuss a variety of genetic instruments and regulatory elements used to activate secondary metabolism cryptic genes for the overproduction of these metabolites.
Starting Page	387
Ending Page	402
Page Count	16
File Format	PDF
ISSN	13675435
Journal	Journal of Industrial Microbiology and Biotechnology
Volume Number	41
Issue Number	2
e-ISSN	14765535
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-10-15
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	Actinomycetes Cryptic gene clusters Synthetic promoters Heterologous expression Genome mining Microbiology Biochemistry Inorganic Chemistry Genetic Engineering Biotechnology Bioinformatics
Content Type	Text
Resource Type	Article
Subject	Medicine Bioengineering Applied Microbiology and Biotechnology Biotechnology

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