NDLI: Anti-oxidant and anti-inflammatory properties of methanol extracts from various crops

Content Provider	Springer Nature Link
Author	Hwang, Jung Min Choi, Ki Choon Bang, Sung Jun Son, Young Ok Kim, Beom Tae Kim, Dong Hern Choi, Gi Jun Kim, Da Hye Shi, Xianglin Lee, Jeong Chae
Copyright Year	2013
Abstract	Corn, sorghum, barley, Italian ryegrass (IRG), and alfalfa have long been used in human and/or animal diets. While their nutritional information is widely available, their potentials for anti-oxidation, anti-inflammation, and anti-tumor are barely explored. In the present study, several serial extracts were prepared from 70% methanol extracts of these forage crops and their bioactive potentials were investigated using cell-free and cell-mediated experimental systems. Chloroform extracts in this study generally showed stronger activity to scavenge hydroxyl radicals and superoxide anions than butanol or water extracts. IRG and sorghum chloroform extracts especially almost completely suppressed the lipopolysaccharide-mediated production of nitric oxide, tumor-necrosis factor-α, and interleukin-6. These extracts also inhibited dramatically the viability and DNA synthesis of human skin dermatofibrosarcoma cells without a toxic effect on primary cultured control cells. These beneficial effects appeared to be associated with the amount of flavonoids contained in the extracts.
Starting Page	265
Ending Page	272
Page Count	8
File Format	PDF
ISSN	12267708
Journal	Food Science and Biotechnology
Volume Number	22
Issue Number	1
e-ISSN	20926456
Language	English
Publisher	The Korean Society of Food Science and Technology
Publisher Date	2013-02-28
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	forage crops reactive oxygen species antiinflammation flavonoid bioactivity Food Science Nutrition
Content Type	Text
Resource Type	Article
Subject	Applied Microbiology and Biotechnology Food Science Biotechnology

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