NDLI: Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease

Content Provider	Springer Nature Link
Author	Soehn, Anne S. Franck, Thomas Biskup, Saskia Giaime, Emilie Melle, Christian Rott, Ruth Cebo, Daniel Kalbacher, Hubert Ott, Erwin Pahnke, Jens Meitinger, Thomas Krüger, Rejko Gasser, Thomas Berg, Daniela Eggeling, Ferdinand Engelender, Simone Costa, Cristine Alves Riess, Olaf
Copyright Year	2009
Abstract	Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of Lewy bodies. Alpha-synuclein and its interactor synphilin-1 are major components of these inclusions. Rare mutations in the α-synuclein and synphilin-1 genes have been implicated in the pathogenesis of PD; however, the normal function of these proteins is far from being completely elucidated. We, thus, searched for novel synphilin-1-interacting proteins and deciphered periphilin as new interactor. Periphilin isoforms are involved in multiple cellular functions in vivo, and the protein is broadly expressed during embryogenesis and in the adult brain. We show that periphilin displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of PD patients. Functional studies demonstrate that periphilin, as previously shown for synphilin-1, displays an antiapoptotic function by reducing caspase-3 activity. Searching for mutations in the periphilin gene, we detected a K69E substitution in two patients of a PD family. Taken together, these findings support for the first time an involvement of periphilin in PD.
Starting Page	203
Ending Page	215
Page Count	13
File Format	PDF
ISSN	13646745
Journal	Neurogenetics
Volume Number	11
Issue Number	2
e-ISSN	13646753
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-09-03
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Parkinson's disease Synphilin-1 Periphilin Alpha-synuclein Protein interaction Lewy bodies Neurosciences Molecular Medicine Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics Cellular and Molecular Neuroscience Genetics (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease

Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice

New α- and γ-synuclein immunopathological lesions in human brain

Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies

Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases

Dementia with Lewy bodies: no association of polymorphisms in the human synphilin gene

A reciprocal relationship between markers of genomic DNA damage and alpha-synuclein pathology in dementia with Lewy bodies

Synphilin-1A is a Phosphoprotein Phosphatase 1-Interacting Protein and Affects PPP1 Sorting to Subcellular Compartments

Dementia with Lewy bodies: an update and outlook

Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease

Similar Documents

Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease

Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice

New α- and γ-synuclein immunopathological lesions in human brain

Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies

Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases

Dementia with Lewy bodies: no association of polymorphisms in the human synphilin gene

A reciprocal relationship between markers of genomic DNA damage and alpha-synuclein pathology in dementia with Lewy bodies

Synphilin-1A is a Phosphoprotein Phosphatase 1-Interacting Protein and Affects PPP1 Sorting to Subcellular Compartments

Dementia with Lewy bodies: an update and outlook

Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease