| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Outeiro, Tiago Fleming Koss, David J. Erskine, Daniel Walker, Lauren Kurzawa-Akanbi, Marzena Burn, David Donaghy, Paul Morris, Christopher Taylor, John-Paul Thomas, Alan Attems, Johannes McKeith, Ian |
| Abstract | Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. Neuropathologically, DLB is characterised by the accumulation of aggregated α-synuclein protein in Lewy bodies and Lewy neurites, similar to Parkinson’s disease (PD). Extrapyramidal motor features characteristic of PD, are common in DLB patients, but are not essential for the clinical diagnosis of DLB. Since many PD patients develop dementia as disease progresses, there has been controversy about the separation of DLB from PD dementia (PDD) and consensus reports have put forward guidelines to assist clinicians in the identification and management of both syndromes. Here, we present basic concepts and definitions, based on our current understanding, that should guide the community to address open questions that will, hopefully, lead us towards improved diagnosis and novel therapeutic strategies for DLB and other synucleinopathies. |
| Related Links | https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/s13024-019-0306-8.pdf |
| Ending Page | 18 |
| Page Count | 18 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17501326 |
| DOI | 10.1186/s13024-019-0306-8 |
| Journal | Molecular Neurodegeneration |
| Issue Number | 1 |
| Volume Number | 14 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2019-01-21 |
| Access Restriction | Open |
| Subject Keyword | Neurosciences Neurology Molecular Medicine Dementia with Lewy bodies Alpha-synuclein Dementia Alzheimer’s disease Biomarkers |
| Content Type | Text |
| Resource Type | Review |
| Subject | Neurology (clinical) Molecular Biology Cellular and Molecular Neuroscience |
| Journal Impact Factor | 15.1/2023 |
| 5-Year Journal Impact Factor | 16.8/2023 |
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