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Charcot-Marie-Tooth disease and related peripheral neuropathies: novel mutations in the peripheral myelin genes connexin 32 (Cx32 ), peripheral myelin protein 22 (PMP22 ), and peripheral myelin protein zero (MPZ )

Neurogenetics : Volume 2

Neurogenetics : Volume 1

Developmental profile of Sry transcripts in mouse brain

Content Provider	Springer Nature Link
Author	Mayer, A. Mosler, G. Just, W. Pilgrim, C. Reisert, I.
Copyright Year	2000
Abstract	Transient activation of the gene Sry in the gonadal ridge during a brief period of embryonic development is believed to function as a key signal for sex determination. However, a number of reports suggest that Sry expression is not as restricted in space and time as one would expect if its role was confined to directing male-specific differentiation in the early gonadal anlage. We have previously reported the occurrence of Sry/SRY transcripts in adult murine and human brain. The present communication is concerned with the study of the ontogenetic time course of Sry transcripts in mouse brain as detected by reverse transcription-polymerase chain reaction (RT-PCR). Particular emphasis was placed on the identification of two different forms of Sry mRNA, which can be linear or circular. To this aim, we used specific RT-PCR strategies to distinguish between both. Sry transcripts were found in male brain tissue of all ontogenetic stages investigated. Circular, presumably untranslatable, transcripts were found in embryonic brains of day 11 through 19. In contrast, postnatal Sry transcripts were linear, and thus translatable, and were found in diencephalon, midbrain, and cortex. The change from one transcript form to the other suggests that expression of the Sry gene in mouse brain is developmentally regulated, presumably by a switch in promoter selection. This supports the notion that Sry expression in brain is biologically significant.
Starting Page	25
Ending Page	30
Page Count	6
File Format	PDF
ISSN	13646745
Journal	Neurogenetics
Volume Number	3
Issue Number	1
Language	English
Publisher	Springer-Verlag
Publisher Date	2000-10-02
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics Cellular and Molecular Neuroscience Genetics (clinical)

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