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| Content Provider | Springer Nature Link |
|---|---|
| Author | Nemoto, Naoki Shida, Yasuo Shimada, Haruo Oshima, Tairo Yamagishi, Akihiko |
| Copyright Year | 2003 |
| Abstract | Polar lipid biosynthesis in the thermoacidophilic archaeon Thermoplasma acidophilum was analyzed using terbinafine, an inhibitor of tetraether lipid biosynthesis. Cells of T. acidophilum were labeled with [14C]mevalonic acid, and their lipids were extracted and analyzed by two-dimensional thin-layer chromatography. Lipids labeled with [14C]mevalonic acid, [14C]glycerol, and [32P]orthophosphoric acid were extracted and hydrolyzed under different conditions to determine the structure of polar lipids. The polar lipids were estimated to be archaetidylglycerol, glycerophosphatidylcaldarchaetidylglycerol, caldarchaetidylglycerol, and β-l-gulopyranosylcaldarchaetidylglycerol, the main polar lipid of T. acidophilum. Pulse and chase experiments with terbinafine revealed that one tetraether lipid molecule is synthesized by head-to-head condensation of two molecules of archaetidylglycerol and that a sugar group of tetraether phosphoglycolipid is expected to attach to the tetraether lipid core after head-to-head condensation in T. acidophilum. A precursor accumulated in the presence of terbinafine with a fast-atom-bombardment mass spectrometry peak m/z 806 was compatible with archaetidylglycerol. The relative height of the peak m/z 806 decreased after removal of the inhibitor. The results suggest that most of the precursor, archaetidylglycerol, is in fully saturated form. |
| Starting Page | 235 |
| Ending Page | 243 |
| Page Count | 9 |
| File Format | |
| ISSN | 14310651 |
| Journal | Extremophiles |
| Volume Number | 7 |
| Issue Number | 3 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2003-02-27 |
| Publisher Place | Tokyo |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Molecular Medicine Microbiology |
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