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Di-myo-inositol phosphate and novel UDP-sugars accumulate in the extreme hyperthermophile Pyrolobus fumarii

Content Provider	Springer Nature Link
Author	Gonçalves, Luís G. Lamosa, Pedro Huber, Robert Santos, Helena
Copyright Year	2008
Abstract	The archaeon Pyrolobus fumarii, one of the most extreme members of hyperthermophiles known thus far, is able to grow at temperatures up to 113°C. Over a decade after the description of this organism our knowledge about the structures and strategies underlying its remarkable thermal resistance remains incipient. The accumulation of a restricted number of charged organic solutes is a common response to heat stress in hyperthermophilic organisms and accordingly their role in thermoprotection has been often postulated. In this work, the organic solute pool of P. fumarii was characterized using 1H, 13C, and 31P NMR. Di-myo-inositol phosphate was the major solute (0.21 μmol/mg protein), reinforcing the correlation between the occurrence of this solute and hyperthermophily; in addition, UDP-sugars (total concentration 0.11 μmol/mg protein) were present. The structures of the two major UDP-sugars were identified as UDP-α-GlcNAc3NAc and UDP-α-GlcNAc3NAc-(4 ← 1)-β-GlcpNAc3NAc. Interestingly, the latter compound appears to be derived from the first one by addition of a 2,3-N-acetylglucoronic acid unit, suggesting that these UDP-sugars are intermediates of an N-linked glycosylation pathway. To our knowledge the UDP-disaccharide has not been reported elsewhere. The physiological roles of these organic solutes are discussed.
Starting Page	383
Ending Page	389
Page Count	7
File Format	PDF
ISSN	14310651
Journal	Extremophiles
Volume Number	12
Issue Number	3
e-ISSN	14334909
Language	English
Publisher	Springer Japan
Publisher Date	2008-02-20
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Compatible solutes Hyperthermophiles Pyrolobus fumarii N-Glycosylation Di-myo-inositol phosphate Ecology Biotechnology Microbiology
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Medicine Microbiology

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