NDLI: The impact of extremophiles on structural genomics (and vice versa)

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Enzymes and proteins from extremophiles as hyperstable probes in nanotechnology: the use of D-trehalose/D-maltose-binding protein from the hyperthermophilic archaeon Thermococcus litoralis for sugars monitoring

The non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPN) of Sulfolobus solfataricus: a key-enzyme of the semi-phosphorylative branch of the Entner–Doudoroff pathway

The 2-oxoacid dehydrogenase multienzyme complex of Haloferax volcanii

Phylogenetic analysis of type I polyketide synthase and nonribosomal peptide synthetase genes in Antarctic sediment

Gene cloning of cold-adapted isocitrate lyase from a psychrophilic bacterium, Colwellia psychrerythraea, and analysis of amino acid residues involved in cold adaptation of this enzyme

Tetraether membrane lipids of Candidatus “Aciduliprofundum boonei”, a cultivated obligate thermoacidophilic euryarchaeote from deep-sea hydrothermal vents

Dihydroxyacetone metabolism in Salinibacter ruber and in Haloquadratum walsbyi

Bacterial diversity and activity along a salinity gradient in soda lakes of the Kulunda Steppe (Altai, Russia)

The in vitro activity of a Rad55 homologue from Sulfolobus tokodaii, a candidate mediator in RadA-catalyzed homologous recombination

Isolation and identification of species of Alicyclobacillus from orchard soil in the Western Cape, South Africa

Acknowledgment to reviewers 2007

Extremophiles : Volume 11

Extremophiles : Volume 10

Extremophiles : Volume 9

Extremophiles : Volume 8

Extremophiles : Volume 7

Extremophiles : Volume 6

Extremophiles : Volume 5

Extremophiles : Volume 4

Extremophiles : Volume 3

Extremophiles : Volume 2

Extremophiles : Volume 1

The impact of extremophiles on structural genomics (and vice versa)

Content Provider	Springer Nature Link
Author	Jenney Jr, Francis E. Adams, Michael W. W.
Copyright Year	2007
Abstract	The advent of the complete genome sequences of various organisms in the mid-1990s raised the issue of how one could determine the function of hypothetical proteins. While insight might be obtained from a 3D structure, the chances of being able to predict such a structure is limited for the deduced amino acid sequence of any uncharacterized gene. A template for modeling is required, but there was only a low probability of finding a protein closely-related in sequence with an available structure. Thus, in the late 1990s, an international effort known as structural genomics (SG) was initiated, its primary goal to “fill sequence-structure space” by determining the 3D structures of representatives of all known protein families. This was to be achieved mainly by X-ray crystallography and it was estimated that at least 5,000 new structures would be required. While the proteins (genes) for SG have subsequently been derived from hundreds of different organisms, extremophiles and particularly thermophiles have been specifically targeted due to the increased stability and ease of handling of their proteins, relative to those from mesophiles. This review summarizes the significant impact that extremophiles and proteins derived from them have had on SG projects worldwide. To what extent SG has influenced the field of extremophile research is also discussed.
Starting Page	39
Ending Page	50
Page Count	12
File Format	PDF
ISSN	14310651
Journal	Extremophiles
Volume Number	12
Issue Number	1
e-ISSN	14334909
Language	English
Publisher	Springer Japan
Publisher Date	2007-06-13
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Structural genomics Open reading frame Extremophiles Thermophiles Hyperthermophiles X-ray crystallography NMR spectroscopy Ecology Biotechnology Microbiology
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Medicine Microbiology

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The impact of extremophiles on structural genomics (and vice versa)

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