NDLI: Phylogenetic analysis of type I polyketide synthase and nonribosomal peptide synthetase genes in Antarctic sediment

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Acknowledgment to reviewers 2007

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Phylogenetic analysis of type I polyketide synthase and nonribosomal peptide synthetase genes in Antarctic sediment

Content Provider	Springer Nature Link
Author	Zhao, Jing Yang, Ning Zeng, Runying
Copyright Year	2007
Abstract	The modular polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) have been found to be involved in natural product synthesis in many microorganisms. Study on their diversities in natural environment may provide important ecological insights, in addition to opportunities for antibacterial drugs development. In this study, the PKS and NRPS gene diversities in two coast sediments near China Zhongshan Station were studied. The phylogenetic analysis of amino acid (AA) sequences indicated that the identified ketosynthase (KS) domains were clustered with those from diverse bacterial groups, including Proteobacteria, Firmicutes, Planctomycetes, Cyanobacteria, Actinobacteria, and some uncultured symbiotic bacteria. One new branch belonging to hybrid PKS/NRPS enzyme complexes and five independent clades were found on the phylogenetic tree. The obtained adenylation (A) domains were mainly clustered within the Cyanobacteria and Proteobacteria group. Most of the identified KS and A domains showed below 80 and 60% identities at the AA level to their closest matches in GenBank, respectively. The diversities of both KS and A domains in natural environmental sample were different from those in sewage-contaminated sample. These results revealed the great diversity and novelty of both PKS and NRPS genes in Antarctic sediment.
Starting Page	97
Ending Page	105
Page Count	9
File Format	PDF
ISSN	14310651
Journal	Extremophiles
Volume Number	12
Issue Number	1
e-ISSN	14334909
Language	English
Publisher	Springer Japan
Publisher Date	2007-08-29
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Polyketide synthase Nonribosomal peptide synthetase Diversity Antarctic Ecology Biotechnology Microbiology
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Medicine Microbiology

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