NDLI: Biological assays and noncovalent interactions of pyridine-2-carbaldehyde thiosemicarbazonecopper(II) drugs with [poly(dA–dT)]2, [poly(dG

Please wait, while we are loading the content...

Elucidation of insulin degrading enzyme catalyzed site specific hydrolytic cleavage of amyloid β peptide: a comparative density functional theory study

Can uranium follow the iron-acquisition pathway? Interaction of uranyl-loaded transferrin with receptor 1

Pulsed EPR investigations of the Mo(V) centers of the R55Q and R55M variants of sulfite dehydrogenase from Starkeya novella

Biological assays and noncovalent interactions of pyridine-2-carbaldehyde thiosemicarbazonecopper(II) drugs with [poly(dA–dT)]2, [poly(dG–dC)]2, and calf thymus DNA

Characterizing metalloendonuclease mixed metal complexes by global kinetic analysis

Gadolinium-containing bioparticles as an active entity to promote cell cycle progression in mouse embryo fibroblast NIH3T3 cells

A systematic investigation of multiheme c-type cytochromes in prokaryotes

Exploring the biochemical mechanisms of cytotoxic gold compounds: a proteomic study

Functional characterization of iron-substituted neural zinc finger factor 1: metal and DNA binding

Design, synthesis, and evaluation of cyclofenil derivatives for potential SPECT imaging agents

Oligonucleotides are potent antioxidants acting primarily through metal ion chelation

Tissue-specific interplay between copper uptake and efflux in Drosophila

JBIC Journal of Biological Inorganic Chemistry : Volume 15, Issue 3, March 2010

JBIC Journal of Biological Inorganic Chemistry : Volume 15, Issue 2, February 2010

JBIC Journal of Biological Inorganic Chemistry : Volume 15, Issue 1, January 2010

JBIC Journal of Biological Inorganic Chemistry : Volume 14

JBIC Journal of Biological Inorganic Chemistry : Volume 13

JBIC Journal of Biological Inorganic Chemistry : Volume 12

JBIC Journal of Biological Inorganic Chemistry : Volume 11

JBIC Journal of Biological Inorganic Chemistry : Volume 10

JBIC Journal of Biological Inorganic Chemistry : Volume 9

JBIC Journal of Biological Inorganic Chemistry : Volume 8

JBIC Journal of Biological Inorganic Chemistry : Volume 7

JBIC Journal of Biological Inorganic Chemistry : Volume 6

JBIC Journal of Biological Inorganic Chemistry : Volume 5

JBIC Journal of Biological Inorganic Chemistry : Volume 4

JBIC Journal of Biological Inorganic Chemistry : Volume 3

JBIC Journal of Biological Inorganic Chemistry : Volume 2

Biological assays and noncovalent interactions of pyridine-2-carbaldehyde thiosemicarbazonecopper(II) drugs with [poly(dA–dT)]2, [poly(dG–dC)]2, and calf thymus DNA

Content Provider	Springer Nature Link
Author	Ruiz, Rebeca García, Begoña Garcia Tojal, Javier Busto, Natalia Ibeas, Saturni Leal, José M. Martins, Célia Gaspar, Jorge Borrás, Joaquín Gil García, Rubén González Álvarez, Marta
Copyright Year	2010
Abstract	The interaction of the Cu(II) drugs CuL(NO3) and CuL′(NO3) (HL is pyridine-2-carbaldehyde thiosemicarbazone and HL′ is pyridine-2-carbaldehyde 4N-methylthiosemicarbazone, in water named [CuL]+ and [CuL′]+) with [poly(dA–dT)]2, [poly(dG–dC)]2, and calf thymus (CT) DNA has been probed in aqueous solution at pH 6.0, I = 0.1 M, and T = 25 °C by absorbance, fluorescence, circular dichroism, and viscosity measurements. The results reveal that these drugs act as groove binders with [poly(dA–dT)]2, with a site size n = 6–7, whereas they act as external binders with [poly(dG–dC)]2 and/or CT-DNA, thus establishing overall electrostatic interaction with n = 1. The binding constants with [CuL′]+ were slightly larger than with [CuL]+. The title compounds display some cleavage activity in the presence of thiols, bringing about the rupture of the DNA strands by the reactive oxygen species formed by reoxidation of Cu(I) to Cu(II); this feature was not observed in the absence of thiols. Mutagenic assays performed both in the presence and in the absence of S9 mix, probed by the Ames test on TA 98, TA 100, and TA 102, were negative. Weak genotoxic activity was detected for [CuL]+ and [CuL′]+, with a significative dose–response effect for [CuL′]+, which was shown to be more cytotoxic in the Ames test and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cell proliferation assays. Methylation of the terminal NH2 group enhances the antiproliferative activity of the pyridine-2-carbaldehyde thiosemicarbazones.
Starting Page	515
Ending Page	532
Page Count	18
File Format	PDF
ISSN	09498257
Journal	JBIC Journal of Biological Inorganic Chemistry
Volume Number	15
Issue Number	4
e-ISSN	14321327
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-01-20
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pyridine-2-carbaldehyde thiosemicarbazone Copper(II) DNA Thermodynamic properties Cytotoxicity Biochemistry Microbiology
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Biological assays and noncovalent interactions of pyridine-2-carbaldehyde thiosemicarbazonecopper(II) drugs with $[poly(dA–dT)]_{2},$ $[poly(dG–dC)]_{2},$ and calf thymus DNA

Binding of tetrakis(pyrazoliumyl)porphyrin and its copper(II) and zinc(II) complexes to poly(dG-dC)2 and poly(dA-dT)2

Interactions of DNA with a new electron‐deficient tentacle porphyrin: meso‐Tetrakis[2,3,5,6‐tetrafluoro‐4‐(2‐trimethylammoniumethylamine)phenyl]porphyrin

Sonication, Fractionation, and Molecular Weight Distribution of Alternating Polydeoxyribonucleotides: Poly(dG-dC) · Poly(dG-dC) and Poly(dA-dT) · Poly(dA-dT)

Copper(II) complexes of N(4)-substituted thiosemicarbazones derived from pyridine-2-carbaldehyde: Crystal structure of a binuclear complex

Bis(ethanol-κO)bis(pyridine-3-carbaldehyde-κN thiosemicarbazone)bis(thiocyanato-κN)iron(II)–pyridine-3-carbaldehyde thiosemicarbazone (1/2)

Helix-helix transitions in DNA: fibre X-ray study of the particular cases poly(dG-dC) · poly(dG-dC) and poly(dA) · 2poly(dT)

Helix-Coil Transition of the Self-Complementary dG-dG-dA-dA-dT-dT-dC-dC Duplex

Platinum(II) and Palladium(II) Complexes of Pyridine-2-Carbaldehyde Thiosemicarbazone as Alternative Antiherpes Simplex Virus Agents

Biological assays and noncovalent interactions of pyridine-2-carbaldehyde thiosemicarbazonecopper(II) drugs with [poly(dA–dT)]2, [poly(dG–dC)]2, and calf thymus DNA

Similar Documents

Biological assays and noncovalent interactions of pyridine-2-carbaldehyde thiosemicarbazonecopper(II) drugs with $[poly(dA–dT)]_{2},$ $[poly(dG–dC)]_{2},$ and calf thymus DNA

Binding of tetrakis(pyrazoliumyl)porphyrin and its copper(II) and zinc(II) complexes to poly(dG-dC)2 and poly(dA-dT)2

Interactions of DNA with a new electron‐deficient tentacle porphyrin: meso‐Tetrakis[2,3,5,6‐tetrafluoro‐4‐(2‐trimethylammoniumethylamine)phenyl]porphyrin

Sonication, Fractionation, and Molecular Weight Distribution of Alternating Polydeoxyribonucleotides: Poly(dG-dC) · Poly(dG-dC) and Poly(dA-dT) · Poly(dA-dT)

Copper(II) complexes of N(4)-substituted thiosemicarbazones derived from pyridine-2-carbaldehyde: Crystal structure of a binuclear complex

Bis(ethanol-κO)bis(pyridine-3-carbaldehyde-κN thiosemicarbazone)bis(thiocyanato-κN)iron(II)–pyridine-3-carbaldehyde thiosemicarbazone (1/2)

Helix-helix transitions in DNA: fibre X-ray study of the particular cases poly(dG-dC) · poly(dG-dC) and poly(dA) · 2poly(dT)

Helix-Coil Transition of the Self-Complementary dG-dG-dA-dA-dT-dT-dC-dC Duplex

Platinum(II) and Palladium(II) Complexes of Pyridine-2-Carbaldehyde Thiosemicarbazone as Alternative Antiherpes Simplex Virus Agents

Biological assays and noncovalent interactions of pyridine-2-carbaldehyde thiosemicarbazonecopper(II) drugs with [poly(dA–dT)]2, [poly(dG–dC)]2, and calf thymus DNA