NDLI: π–π interaction between aromatic ring and copper-coordinated His81 imidazole regulates the blue copper active-site structure

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π–π interaction between aromatic ring and copper-coordinated His81 imidazole regulates the blue copper active-site structure

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JBIC Journal of Biological Inorganic Chemistry : Volume 12, Issue 1, January 2007

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π–π interaction between aromatic ring and copper-coordinated His81 imidazole regulates the blue copper active-site structure

Content Provider	Springer Nature Link
Author	Abdelhamid, Rehab F. Obara, Yuji Uchida, Yoshiko Kohzuma, Takamitsu Dooley, David M. Brown, Doreen E. Hori, Hiroshi
Copyright Year	2006
Abstract	Noncovalent weak interactions play important roles in biological systems. In particular, such interactions in the second coordination shell of metal ions in proteins may modulate the structure and reactivity of the metal ion site in functionally significant ways. Recently, π–π interactions between metal ion coordinated histidine imidazoles and aromatic amino acids have been recognized as potentially important contributors to the properties of metal ion sites. In this paper we demonstrate that in pseudoazurin (a blue copper protein) the π–π interaction between a coordinated histidine imidazole ring and the side chains of aromatic amino acids in the second coordination sphere, significantly influences the properties of the blue copper site. Electronic absorption and electron paramagnetic resonance spectra indicate that the blue copper electronic structure is perturbed, as is the redox potential, by the introduction of a second coordination shell π–π interaction. We suggest that the π–π interaction with the metal ion coordinated histidine imidazole ring modulates the electron delocalization in the active site, and that such interactions may be functionally important in refining the reactivity of blue copper sites.
Starting Page	165
Ending Page	173
Page Count	9
File Format	PDF
ISSN	09498257
Journal	JBIC Journal of Biological Inorganic Chemistry
Volume Number	12
Issue Number	2
e-ISSN	14321327
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-10-10
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Blue copper protein Pseudoazurin Electron paramagnetic resonance Electrochemistry Weak interaction Microbiology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

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