NDLI: Inhibition of DNA alkylation damage with inorganic salts

Content Provider	Springer Nature Link
Author	Hamilton, Elizabeth E. Wilker, Jonathan J.
Copyright Year	2004
Abstract	Human exposure to alkylating agents metabolized from tobacco- and food-borne carcinogens occurs regularly. Dietary inorganic compounds such as selenium and vanadium have been shown previously to provide chemoprotective benefits in rat and human trials. Here, we present biochemical data on the ability of inorganic compounds to protect DNA from alkylation damage. An enzyme cleavage assay is used to observe alkylated DNA. Simple salts (e.g., NaCl or NiCl2) did not prevent DNA alkylation, whereas anionic oxo species (e.g., Na2SeO4 or Na3VO4) did inhibit alkylation. We propose that these oxo species behave as nucleophilic targets for the electrophilic alkylating agents, thereby preventing DNA damage.
Starting Page	894
Ending Page	902
Page Count	9
File Format	PDF
ISSN	09498257
Journal	JBIC Journal of Biological Inorganic Chemistry
Volume Number	9
Issue Number	7
e-ISSN	14321327
Language	English
Publisher	Springer-Verlag
Publisher Date	2004-09-16
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Chemoprevention DNA alkylation DNA damage Selenium Vanadium
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

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Inhibition of DNA alkylation damage with inorganic salts