NDLI: The DNSev™ expert system in the auto-verification of tumour markers and hormones results

Content Provider	Springer Nature Link
Author	Dorizzi, Romolo M. Caruso, Beatrice Meneghelli, Sandra Rizzotti, Paolo
Copyright Year	2006
Abstract	Most of the immunoassays workload is processed in clinical laboratories within a time span comparable to the clinical chemistry and the haematology assays and the analytical work is usually completed between 1:00 and 2:00 p.m. In order to accelerate the auto-verification of the results of tumour markers (Total and free PSA, CEA, CA 125, CA 15-3, CA 19-9, TPA, AFP, NSE, S 100 protein), and hormones (TSH, FT4, FT3, Prolactin, total testosterone) and Procalcitonin (PCT) we used DNSevTM expert system implementing 13 rules based on decision levels/reference intervals and reference change values. The auto-verification procedure has been implemented after a 6-month trial in June 2004 and in 2005 the immunoassays section supervisor was able to verify about 500 results in about 30 min 5 days/week. We conclude that the auto-verification of immunoassays implemented in our laboratory is fast and consistent among different supervisors and leaves more time for an effective and timely interaction with clinicians and general practitioners.
Starting Page	303
Ending Page	307
Page Count	5
File Format	PDF
ISSN	09491775
Journal	Accreditation and Quality Assurance
Volume Number	11
Issue Number	6
e-ISSN	14320517
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-06-07
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Auto-verification Auto-validation Tumour markers Hormones Reference change value Marketing Ecotoxicology Commercial Law Biochemistry Food Science Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Instrumentation Chemical Engineering Safety, Risk, Reliability and Quality

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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