NDLI: Sensitivity and significance of disease outcome measures in inflammatory bowel disease

Please wait, while we are loading the content...

Towards quality specifications in extra-analytical phases of laboratory services: What information on quality specifications should be communicated to clinicians, and how?

Sensitivity and significance of disease outcome measures in inflammatory bowel disease

The DNSev™ expert system in the auto-verification of tumour markers and hormones results

Estimation of the biological variation of glucose-6-phosphate dehydrogenase in dried blood spots

Internationalisation of scientific reports on life tests

Congresses, Meetings, Workshops and Courses

Accreditation and Quality Assurance : Volume 11, Issue 5, June 2006

Accreditation and Quality Assurance : Volume 11, Issue 4, May 2006

Accreditation and Quality Assurance : Volume 11, Issue 3, May 2006

Accreditation and Quality Assurance : Volume 11, Issue 1-2, April 2006

Accreditation and Quality Assurance : Volume 10

Accreditation and Quality Assurance : Volume 9

Accreditation and Quality Assurance : Volume 8

Accreditation and Quality Assurance : Volume 7

Accreditation and Quality Assurance : Volume 6

Accreditation and Quality Assurance : Volume 5

Accreditation and Quality Assurance : Volume 4

Accreditation and Quality Assurance : Volume 3

Accreditation and Quality Assurance : Volume 2

Sensitivity and significance of disease outcome measures in inflammatory bowel disease

Content Provider	Springer Nature Link
Author	Jørgensen, Lone G. M.
Copyright Year	2006
Abstract	In inflammatory bowel disease (IBD), proxy measures of clinical outcome are often collected into summary indices of qualitative self-rated disease markers, clinical observations, and quantitative biochemical analyses. In Crohn's disease (CD), a frequently used index is the Crohn's disease activity index (DCAI). This index consists of six qualitative variables and two quantitative variables. The aim of this presentation is to illustrate the use of this index to calculate its range, to estimate errors in the index, its sensitivity, and the number of significant steps in the index. The measure of sensitivity of the summary index was analyzed for the signal-to-noise ratio (SNR), the reference change value (RCV) and the confidence interval (CI). If identical errors were assumed in patient self-rated health and clinically judged disease manifestations, such as tumours and fistulas, the majority of the variance of the index was caused by the self-rated experience of health, the number of days over which the individual variable was rated, and the prognostic multiplier of each variable.The range of the index has no upper limit, but can be estimated to 403 units, of which patient self-rating of well-being account for up to one-third of the summary index maximal score range. The median signal noise measure of index sensitivity was 18 SDs. The two disease classification limits of 150 units for moderate disease and 450 for severe disease on average cover an interval of limit ±41.5 units vs. ±60.5 units. In judgments on change in clinical outcome the RCV interval of steps of 121 units are valid. Conclusion: Both variance and range of the CDAI summary score are primarily decided by the self-rated experience of well-being. Variables on disease signs have a minor impact on the index. Rating of the two important outcome parameters: Self-experienced health and medical outcome would favourably be given in two individual scores.
Starting Page	297
Ending Page	302
Page Count	6
File Format	PDF
ISSN	09491775
Journal	Accreditation and Quality Assurance
Volume Number	11
Issue Number	6
e-ISSN	14320517
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-05-04
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Clinical outcome Crohn's disease Inflammatory bowel disease Prognostic factors Quality assessment Signal-to-noise ratio Ulcerative colitis Marketing Ecotoxicology Commercial Law Biochemistry Food Science Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Instrumentation Chemical Engineering Safety, Risk, Reliability and Quality

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A94 IS IBD-CONTROL QUESTIONNAIRE A RELIABLE PATIENT REPORTED OUTCOME IN ADOLESCENTS WITH INFLAMMATORY BOWEL DISEASE?

Safety and Efficacy of Bevacizumab in Cancer Patients with Inflammatory Bowel Disease

Quality improvement in wellness reports in patients with Crohn’s disease

Prognostication in inflammatory bowel disease

Meeting quality

Characterization of Serum Cytokine Profile in Predominantly Colonic Inflammatory Bowel Disease to Delineate Ulcerative and Crohn's Colitides

Low-frequency noise in analytical soil measurements

Corrosion and Quality

Quality of Life After Restorative Proctocolectomy for Ulcerative Colitis: Different Questionnaires Lead to Different Interpretations

Sensitivity and significance of disease outcome measures in inflammatory bowel disease

Similar Documents

A94 IS IBD-CONTROL QUESTIONNAIRE A RELIABLE PATIENT REPORTED OUTCOME IN ADOLESCENTS WITH INFLAMMATORY BOWEL DISEASE?

Safety and Efficacy of Bevacizumab in Cancer Patients with Inflammatory Bowel Disease

Quality improvement in wellness reports in patients with Crohn’s disease

Prognostication in inflammatory bowel disease

Meeting quality

Characterization of Serum Cytokine Profile in Predominantly Colonic Inflammatory Bowel Disease to Delineate Ulcerative and Crohn's Colitides

Low-frequency noise in analytical soil measurements

Corrosion and Quality

Quality of Life After Restorative Proctocolectomy for Ulcerative Colitis: Different Questionnaires Lead to Different Interpretations

Sensitivity and significance of disease outcome measures in inflammatory bowel disease