NDLI: Simulated environmental criticalities affect transglutaminase of Malus and Corylus pollens having different allergenic potential

Content Provider	Springer Nature Link
Author	Iorio, Rosa Anna Di Sandro, Alessia Paris, Roberta Pagliarani, Giulia Tartarini, Stefa Ricci, Giampaolo Serafini Fracassini, Donatella Verderio, Elisabetta Del Duca, Stefa
Copyright Year	2011
Abstract	Increases in temperature and air pollution influence pollen allergenicity, which is responsible for the dramatic raise in respiratory allergies. To clarify possible underlying mechanisms, an anemophilous pollen (hazel, Corylus avellana), known to be allergenic, and an entomophilous one (apple, Malus domestica), the allergenicity of which was not known, were analysed. The presence also in apple pollen of known fruit allergens and their immunorecognition by serum of an allergic patient were preliminary ascertained, resulting also apple pollen potentially allergenic. Pollens were subjected to simulated stressful conditions, provided by changes in temperature, humidity, and copper and acid rain pollution. In the two pollens exposed to environmental criticalities, viability and germination were negatively affected and different transglutaminase (TGase) gel bands were differently immunodetected with the polyclonal antibody AtPng1p. The enzyme activity increased under stressful treatments and, along with its products, was found to be released outside the pollen with externalisation of TGase being predominant in C. avellana, whose grain presents a different cell wall composition with respect to that of M. domestica. A recombinant plant TGase (AtPng1p) stimulated the secreted phospholipase A2 (sPLA2) activity, that in vivo is present in human mucosa and is involved in inflammation. Similarly, stressed pollen, hazel pollen being the most efficient, stimulated to very different extent sPLA2 activity and putrescine conjugation to sPLA2. We propose that externalised pollen TGase could be one of the mediators of pollen allergenicity, especially under environmental stress induced by climate changes.
Starting Page	1007
Ending Page	1024
Page Count	18
File Format	PDF
ISSN	09394451
Journal	Amino Acids
Volume Number	42
Issue Number	2-3
e-ISSN	14382199
Language	English
Publisher	Springer Vienna
Publisher Date	2011-08-17
Publisher Place	Vienna
Access Restriction	Subscribed
Subject Keyword	Climate changes Environmental pollution Phospholipase A2 Pollen allergenicity Respiratory allergies Transglutaminase Neurobiology Life Sciences Biochemistry Proteomics Biochemical Engineering Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Clinical Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Transglutaminase 2 and phospholipase A2 interactions in the inflammatory response in human Thp-1 monocytes

Impact of climate changes on pollen and respiratory allergies

Polyamines and transglutaminase activity are involved in compatible and self-incompatible pollination of Citrus grandis

Compatible and self-incompatible pollination in Pyrus communis displays different polyamine levels and transglutaminase activity

Transglutaminase 2 and neuroinflammation

Phthalocyanine-dyed fibers adsorb allergenic proteins

Transglutaminase as polyamine mediator in plant growth and differentiation

Transglutaminase 2, a double face enzyme

Tissue transglutaminase and the stress response

Simulated environmental criticalities affect transglutaminase of Malus and Corylus pollens having different allergenic potential

Similar Documents

Transglutaminase 2 and phospholipase A2 interactions in the inflammatory response in human Thp-1 monocytes

Impact of climate changes on pollen and respiratory allergies

Polyamines and transglutaminase activity are involved in compatible and self-incompatible pollination of Citrus grandis

Compatible and self-incompatible pollination in Pyrus communis displays different polyamine levels and transglutaminase activity

Transglutaminase 2 and neuroinflammation

Phthalocyanine-dyed fibers adsorb allergenic proteins

Transglutaminase as polyamine mediator in plant growth and differentiation

Transglutaminase 2, a double face enzyme

Tissue transglutaminase and the stress response

Simulated environmental criticalities affect transglutaminase of Malus and Corylus pollens having different allergenic potential